Last update Jan. 15, 2023

ثنائي سولفيرام

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

It is a carbamate derivative that is used to treat alcohol addiction. Disulfiram inhibits an enzyme responsible for the oxidation of an alcohol metabolite, which accumulates and causes very unpleasant effects even with small amounts of alcohol, such as that found in some medications. Oral administration once a day.

At the date of the last update we did not find any published data on its excretion in breast milk.

Its high binding to plasma proteins makes it difficult to pass into breast milk.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

TOPICAL USE:

Topically it has been used to treat exoparasites such as lice or scabies. (Lajarin2022)

The poor plasma absorption of most topical dermatological preparations makes it unlikely that a significant amount will pass into breast milk. Do not apply on the breasts to prevent the infant from ingesting it.

Alternatives

  • Almotriptan Malate (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Dimeticone; Dimethicone (Safe substance and/or breastfeeding is the best option.)
  • Naltrexone Hydrochloride (Safe substance and/or breastfeeding is the best option.)
  • Permethrin (Safe substance and/or breastfeeding is the best option.)
  • Piperonyl Butoxide (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Pyrethrin (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

ثنائي سولفيرام is Disulfiram in Arabic.

Is written in other languages:

ثنائي سولفيرام is also known as

Tradenames

Main tradenames from several countries containing ثنائي سولفيرام in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 80 %
Molecular weight 296 daltons
Protein Binding 96 %
Tmax 1.8 - 3.3 hours
6 - 11 hours

References

  1. Lajarin-Reinares M, Martinez-Esteve E, Pena-Rodríguez E, Cañellas-Santos M, Bulut S, Karabelas K, Clauss A, Nieto C, Mallandrich M, Fernandez-Campos F. The Efficacy and Biopharmaceutical Properties of a Fixed-Dose Combination of Disulfiram and Benzyl Benzoate. Int J Mol Sci. 2022 Sep 19;23(18). pii: 10969. Abstract Full text (link to original source)
  2. Johansson B. A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites. Acta Psychiatr Scand Suppl. 1992;369:15-26. Review. Abstract

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