Last update Dec. 8, 2019

Piperonyl Butoxide

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Piperonyl butoxide is used as a synergist mixed with piperonyl and pyrethrins or pyrethroids in the treatment of pediculosis, head and body lice and pubis (crabs).

Its cutaneous absorption is minimal, around 2% (Buist 2005, Selim 1999), so it is unlikely that it reaches significant concentrations in breast milk.

Its sporadic use is compatible with breastfeeding.

Avoid applying it on the breast or nipple. Otherwise, cleanse it thoroughly before nursing.


  • Permethrin ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Piperonyl Butoxide in other languages or writings:


Piperonyl Butoxide belongs to this group or family:


Variable Value Unit
Oral Bioavail. Dermat: ≈ 2 %
Molecular weight 338 daltons


  1. Buist HE, van de Sandt JJ, van Burgsteden JA, de Heer C. Effects of single and repeated exposure to biocidal active substances on the barrier function of the skin in vitro. Regul Toxicol Pharmacol. 2005 Oct;43(1):76-84. Abstract
  2. Selim S, Preiss FJ, Gabriel KL, Jonkman JH, Osimitz TG. Absorption and mass balance of piperonyl butoxide following an 8-h dermal exposure in human volunteers. Toxicol Lett. 1999 Jun 30;107(1-3):207-17. Abstract

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