Last update Jan. 15, 2023

Éthyldithiourame; Tetraethylthiuram disulfide (TTD)

High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

It is a carbamate derivative that is used to treat alcohol addiction. Disulfiram inhibits an enzyme responsible for the oxidation of an alcohol metabolite, which accumulates and causes very unpleasant effects even with small amounts of alcohol, such as that found in some medications. Oral administration once a day.

At the date of the last update we did not find any published data on its excretion in breast milk.

Its high binding to plasma proteins makes it difficult to pass into breast milk.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.


Topically it has been used to treat exoparasites such as lice or scabies. (Lajarin2022)

The poor plasma absorption of most topical dermatological preparations makes it unlikely that a significant amount will pass into breast milk. Do not apply on the breasts to prevent the infant from ingesting it.


  • Almotriptan Malate (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Dimeticone; Dimethicone ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Naltrexone Hydrochloride ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Permethrin ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Piperonyl Butoxide (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Pyrethrin ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Éthyldithiourame; Tetraethylthiuram disulfide (TTD) is also known as Disulfiram.

Éthyldithiourame; Tetraethylthiuram disulfide (TTD) in other languages or writings:


Éthyldithiourame; Tetraethylthiuram disulfide (TTD) belongs to these groups or families:


Main tradenames from several countries containing Éthyldithiourame; Tetraethylthiuram disulfide (TTD) in its composition:


Variable Value Unit
Oral Bioavail. 80 %
Molecular weight 296 daltons
Protein Binding 96 %
Tmax 1.8 - 3.3 hours
6 - 11 hours


  1. Lajarin-Reinares M, Martinez-Esteve E, Pena-Rodríguez E, Cañellas-Santos M, Bulut S, Karabelas K, Clauss A, Nieto C, Mallandrich M, Fernandez-Campos F. The Efficacy and Biopharmaceutical Properties of a Fixed-Dose Combination of Disulfiram and Benzyl Benzoate. Int J Mol Sci. 2022 Sep 19;23(18). pii: 10969. Abstract Full text (link to original source)
  2. Johansson B. A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites. Acta Psychiatr Scand Suppl. 1992;369:15-26. Review. Abstract

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