Last update Oct. 12, 2022

C10 H15 NO

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

An alkaloid derived from ephedra. It has sympathomimetic properties with direct and indirect effects on adrenergic receptors. Used parenterally to treat hypotension derived from spinal or epidural anesthesia due to its peripheral vasoconstrictor effects and improvement of heart tone. Used orally as a bronchodilator and nasal decongestant mixed in preparations for colds, bronchitis and asthma. Topical use: local anesthetic, dermatological, stomatological and ophthalmologicalUsed illegaly as a psychostimulant and for weight loss, with serious health risks. (van der Hoof 2002, Gruber 1998)

Since the last update we have not found published data on its excretion in breast milk.

Its large volume of distribution makes it unlikely it will pass into milk in significant amounts.

After a cesarean section with epidural anesthesia and use of ephedrine there were no side effects in 100 newborns; the time of initial breastfeeding was not delayed with respect to newborns after cesareans under general anesthesia (Havas 2013). The use of ephedrine during delivery or cesarean section is not contraindicated with the early initiation of breastfeeding: as well as the unlikely excretion in breast milk there is a low amount of colostrum obtained by the newborn in the first hours of life.

It may be desirable to minimize the continued use of oral preparations for colds/bronchitis which contain ephedrine since a case of crying, irritability and insomnia has been reported in a 3-month-old infant whose mother was taking a medication containing d-isoephedrine and dexbrompheniramine.(Mortimer 1977)

Simple preparations (a single active ingredient per drug) are preferable and even more so during breastfeeding. Abusive use as a psychostimulant or antiobesity product entails serious risks to the health of the mother and the infant and should be avoided. (van der Hoof 2002, Gruber 1998)

There is good quality evidence that exclusive breastfeeding helps to regain pre-pregnancy weight earlier than if breastfeeding is partial (mixed) or there is no breastfeeding, and that prolonged breastfeeding helps maintain that loss and as well as body fat loss.(Jayasinghe 2021, Schalla 2017, López 2016, Jarlenski 2014, Sámano 2013, Neville 2014, Hatsu 2008, Dewey 2004, 2001 y 1993, Kramer 1993)

Some authors consider oral and nasal decongestant drugs dispensable drugs, to be avoided in general, not only during lactation, since they expose patients to serious risks (cardiovascular, neurological and intestinal) to treat a benign alteration such as nasal obstruction , which usually progresses favorably in a few days without medication. (Prescrire 2018)

TOPICAL USE:

Correctly applied topical ephedrine preparations have virtually no systemic absorption. (AEMPS 2008)

Avoid applying it on the breast, otherwise, cleanse the area thoroughly and/or do it after having nursed.

Ephedrine as a complement to preparations for local anesthetic, dermatologicals, stomatologicals or ophthalmologicals is compatible with breastfeeding. (WHO 2002)


See below the information of these related products:

  • Cytisine ( Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.)
  • Ephedra ( Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.)

Alternatives

  • Adrenaline ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Albuterol ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Dobutamine Hydrochloride ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Hypocaloric Diet ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Liraglutide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Maternal Sport ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Metformin Hydrochloride ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Norepinephrine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Orlistat (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Terbutaline Sulfate ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

C10 H15 NO is Ephedrine in Molecular formula.

Is written in other languages:

C10 H15 NO is also known as

Tradenames

Main tradenames from several countries containing C10 H15 NO in its composition:

  • Akovaz
  • Bideon Free™. Contains other elements than C10 H15 NO in its composition
  • Bisolvon Compositum (Argentina)™. Contains other elements than C10 H15 NO in its composition
  • Broncofedrina™. Contains other elements than C10 H15 NO in its composition
  • Bronkotuss Expectorant™. Contains other elements than C10 H15 NO in its composition
  • CAM
  • Coliria™. Contains other elements than C10 H15 NO in its composition
  • Colirio Iris
  • Corphedra
  • Dalmacol™. Contains other elements than C10 H15 NO in its composition
  • Dolvan™. Contains other elements than C10 H15 NO in its composition
  • Emerphed
  • Etrilect™. Contains other elements than C10 H15 NO in its composition
  • Fienamina™. Contains other elements than C10 H15 NO in its composition
  • Franol™. Contains other elements than C10 H15 NO in its composition
  • Fu Ma (呋麻滴鼻液)
  • Haymine™. Contains other elements than C10 H15 NO in its composition
  • Hemoal™. Contains other elements than C10 H15 NO in its composition
  • Hydrophed™. Contains other elements than C10 H15 NO in its composition
  • Kalopsis™. Contains other elements than C10 H15 NO in its composition
  • Kondon's Nasal
  • Marax™. Contains other elements than C10 H15 NO in its composition
  • Metaphed
  • Mollipect™. Contains other elements than C10 H15 NO in its composition
  • Mollisupradin™. Contains other elements than C10 H15 NO in its composition
  • Muchan
  • Noradran™. Contains other elements than C10 H15 NO in its composition
  • Paranorm™. Contains other elements than C10 H15 NO in its composition
  • Pazbronquial™. Contains other elements than C10 H15 NO in its composition
  • Pectocalmine N™. Contains other elements than C10 H15 NO in its composition
  • Pidrol™. Contains other elements than C10 H15 NO in its composition
  • Primatene™. Contains other elements than C10 H15 NO in its composition
  • Quadrinal™. Contains other elements than C10 H15 NO in its composition
  • Quelidrine™. Contains other elements than C10 H15 NO in its composition
  • Rezipres
  • Sival-B™. Contains other elements than C10 H15 NO in its composition
  • Spinefe
  • Tedrigen™. Contains other elements than C10 H15 NO in its composition
  • Tendrin
  • Theodrine™. Contains other elements than C10 H15 NO in its composition
  • Theomax DF™. Contains other elements than C10 H15 NO in its composition
  • Unifedrine

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 88 %
Molecular weight 165 daltons
Protein Binding 4.9 ± 0.3 %
VD 3.1 l/Kg
pKa 13.89 -
Tmax 0.25 - 1 hours
3 - 6 hours

References

  1. Jayasinghe S, Herath MP, Beckett JM, Ahuja KDK, Byrne NM, Hills AP. Exclusivity of breastfeeding and body composition: learnings from the Baby-bod study. Int Breastfeed J. 2021 May 19;16(1):41. Abstract Full text (link to original source)
  2. MedlinePlus. Fitoterapia y suplementos para bajar de peso. Información de salud para usted. 2019 Full text (link to original source) Full text (in our servers)
  3. MedlinePlus. Herbal remedies and supplements for weight loss. Trusted Health information for you 2019 Full text (link to original source) Full text (in our servers)
  4. Schalla SC, Witcomb GL, Haycraft E. Body Shape and Weight Loss as Motivators for Breastfeeding Initiation and Continuation. Int J Environ Res Public Health. 2017 Jul 11;14(7). pii: E754. Abstract Full text (link to original source)
  5. López-Olmedo N, Hernández-Cordero S, Neufeld LM, García-Guerra A, Mejía-Rodríguez F, Méndez Gómez-Humarán I. The Associations of Maternal Weight Change with Breastfeeding, Diet and Physical Activity During the Postpartum Period. Matern Child Health J. 2016 Feb;20(2):270-80. Abstract
  6. Neville CE, McKinley MC, Holmes VA, Spence D, Woodside JV. The relationship between breastfeeding and postpartum weight change--a systematic review and critical evaluation. Int J Obes (Lond). 2014 Apr;38(4):577-90. Abstract
  7. Jarlenski MP, Bennett WL, Bleich SN, Barry CL, Stuart EA. Effects of breastfeeding on postpartum weight loss among U.S. women. Prev Med. 2014 Dec;69:146-50. Abstract Full text (link to original source)
  8. Havas F, Orhan Sungur M, Yenigün Y, Karadeniz M, Kılıç M, Özkan Seyhan T. Spinal anesthesia for elective cesarean section is associated with shorter hospital stay compared to general anesthesia. Agri. 2013 Abstract Full text (link to original source) Full text (in our servers)
  9. Sámano R, Martínez-Rojano H, Godínez Martínez E, Sánchez Jiménez B, Villeda Rodríguez GP, Pérez Zamora J, Casanueva E. Effects of breastfeeding on weight loss and recovery of pregestational weight in adolescent and adult mothers. Food Nutr Bull. 2013 Jun;34(2):123-30. Abstract
  10. AEMPS Hemoal (Benzocaína + Efedrina). Ficha técnica. 2008 Full text (in our servers)
  11. Hatsu IE, McDougald DM, Anderson AK. Effect of infant feeding on maternal body composition. Int Breastfeed J. 2008 Aug 6;3:18. Abstract Full text (link to original source)
  12. Dewey KG. Impact of breastfeeding on maternal nutritional status. Adv Exp Med Biol. 2004;554:91-100. Review. Abstract
  13. van der Hooft CS, Stricker BH. [Ephedrine and ephedra in weight loss products and other preparations]. Ned Tijdschr Geneeskd. 2002 Abstract
  14. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  15. Dewey KG, Cohen RJ, Brown KH, Rivera LL. Effects of exclusive breastfeeding for four versus six months on maternal nutritional status and infant motor development: results of two randomized trials in Honduras. J Nutr. 2001 Feb;131(2):262-7. Abstract Full text (link to original source) Full text (in our servers)
  16. Gruber AJ, Pope HG Jr. Ephedrine abuse among 36 female weightlifters. Am J Addict. 1998 Abstract
  17. Kramer FM, Stunkard AJ, Marshall KA, McKinney S, Liebschutz J. Breast-feeding reduces maternal lower-body fat. J Am Diet Assoc. 1993 Apr;93(4):429-33. Abstract
  18. Dewey KG, Heinig MJ, Nommsen LA. Maternal weight-loss patterns during prolonged lactation. Am J Clin Nutr. 1993 Aug;58(2):162-6. Abstract
  19. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977 Abstract
  20. Pickup ME, May CS, Ssendagire R, Paterson JW. The pharmacokinetics of ephedrine after oral dosage in asthmatics receiving acute and chronic treatment. Br J Clin Pharmacol. 1976 Abstract

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