Last update Aug. 5, 2022

Norepinephrine

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

It is a powerful adrenergic stimulant. It produces peripheral vasoconstriction and increases blood pressure. Used in hypotensive states such as shock and cardiac arrest. intravenous administration.

Since the last update we have not found published data on its excretion in breastmilk.

Its rapid metabolism (short TMax and T1/2, less than 1 and 3 minutes, respectively) make it very unlikely that significant quantities will pass into breast milk.

Furthermore, it is destroyed in the gastrointestinal tract. The low oral-bioavailability makes its levels into infant's plasma, that would be absorbed from ingested breast milk, be nil or negligible. (Kearney 2018)

Small amounts of norepinephrine are synthesized in the lactocyte and are present in breast milk. (Chiba 2021)

Expert authors consider the use of this medication compatible during breastfeeding. (Hale, LactMed Kearney 2018)

Alternatives

We do not have alternatives for Norepinephrine since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Norepinephrine is also known as


Norepinephrine in other languages or writings:

Group

Norepinephrine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Norepinephrine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight 169 daltons
Protein Binding 25 %
VD 0.13 l/Kg
pKa 9.5 -
Tmax 0.001 hours
0.04 hours

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on March 17, 2022 Full text (link to original source)
  2. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on March 15, 2022 Full text (link to original source)
  3. Chiba T, Takaguri A, Maeda T. Norepinephrine transporter expressed on mammary epithelial cells incorporates norepinephrine in milk into the cells. Biochem Biophys Res Commun. 2021 Mar 19;545:1-7. Abstract
  4. Kearney L, Wright P, Fhadil S, Thomas M. Postpartum Cardiomyopathy and Considerations for Breastfeeding. Card Fail Rev. 2018 Abstract Full text (link to original source) Full text (in our servers)

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