Last update Aug. 5, 2022

C01CA03

Compatible

Safe substance and/or breastfeeding is the best option.

It is a powerful adrenergic stimulant. It produces peripheral vasoconstriction and increases blood pressure. Used in hypotensive states such as shock and cardiac arrest. intravenous administration.

Since the last update we have not found published data on its excretion in breastmilk.

Its rapid metabolism (short TMax and T1/2, less than 1 and 3 minutes, respectively) make it very unlikely that significant quantities will pass into breast milk.

Furthermore, it is destroyed in the gastrointestinal tract. The low oral-bioavailability makes its levels into infant's plasma, that would be absorbed from ingested breast milk, be nil or negligible. (Kearney 2018)

Small amounts of norepinephrine are synthesized in the lactocyte and are present in breast milk. (Chiba 2021)

Expert authors consider the use of this medication compatible during breastfeeding. (Hale, LactMed Kearney 2018)

Alternatives

We do not have alternatives for C01CA03 since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

C01CA03 is Norepinephrine in ATC Code/s.

Is written in other languages:

C01CA03 is also known as

Group

C01CA03 belongs to this group or family:

Tradenames

Main tradenames from several countries containing C01CA03 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight 169 daltons
Protein Binding 25 %
VD 0.13 l/Kg
pKa 9.5 -
Tmax 0.001 hours
T½ 0.04 hours

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Chiba T, Takaguri A, Maeda T. Norepinephrine transporter expressed on mammary epithelial cells incorporates norepinephrine in milk into the cells. Biochem Biophys Res Commun. 2021 Mar 19;545:1-7. Abstract
  4. Kearney L, Wright P, Fhadil S, Thomas M. Postpartum Cardiomyopathy and Considerations for Breastfeeding. Card Fail Rev. 2018 Abstract Full text (link to original source) Full text (in our servers)

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