Last update Nov. 15, 2022


High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

Is an alkaloid found in plants of the Fabaceae family, Laburnum and Cytisus genera, and other leguminous plants. It has chemical structure, actions and adverse effects similar to nicotine (it is a partial nicotinic acetylcholine agonist). It is used as a smoking cessation treatment. Oral administration several times daily for 25 days.

At the date of the last update, we found no published data on its excretion in breast milk.

The most common adverse reactions are gastrointestinal symptoms of mild or moderate severity (Tutka 2019). It can also cause irritability, hypertension, and tachycardia.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cytisine is also known as

Cytisine in other languages or writings:


Cytisine belongs to this group or family:


Main tradenames from several countries containing Cytisine in its composition:


Variable Value Unit
Oral Bioavail. > 90 %
Molecular weight 190 daltons
VD 2 - 6.2 l/Kg
Tmax 0.9 hours
4.8 hours


  1. AEMPS. Citisina. Ficha técnica. 2022 Full text (in our servers)
  2. Gotti C, Clementi F. Cytisine and cytisine derivatives. More than smoking cessation aids. Pharmacol Res. 2021 Aug;170:105700. Abstract Full text (link to original source)
  3. Tutka P, Vinnikov D, Courtney RJ, Benowitz NL. Cytisine for nicotine addiction treatment: a review of pharmacology, therapeutics and an update of clinical trial evidence for smoking cessation. Addiction. 2019 Nov;114(11):1951-1969. Abstract

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