Last update July 3, 2022
Selective inhibitor of the neuronal reuptake of catecholamines (noradrenaline and dopamine). It is used as an antidepressant and to help stop smoking (Baraona 2017). Administered orally, one daily dose.
Although the concentration in milk is much higher than the plasma concentration, it is excreted in breast milk in very small amounts. (Neuman 2014, Davis 2009, Haas 2004, Briggs 1993)
The plasma levels of infants whose mothers were taking it were undetectable or very low. (Neuman 2014, Davis 2009, Baab 2002, Briggs 1993)
Given the negligible excretion in milk, the absence of plasma levels in infants and the fact that no problems were observed in infants in several publications (Nonacs 2005, Baab 2002, Briggs 1993), two cases of seizures in infants whose mothers were taking bupropion are difficult to explain, whether in monotherapy (Chaudron 2004) or associated with other antidepressants (Neuman 2014). Progress was satisfactory.
Bupropion does not alter prolactin levels. (Whiteman 1982). A case of galactorrhea has been published.(Çam 2015)
Avoid in mothers with a history of epilepsy since it decreases the seizure threshold.
Several experts consider the use of this medication probably safe during breastfeeding. (Hale, Lactmed, Uguz 2021)
Until there is more published data on this drug in relation to breastfeeding, safer alternatives known may be preferable (Sriraman 2015, Carson 2013, Berle 2011, Davanzo 2011), especially during the neonatal period and in case of prematurity.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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