Bupropion-Hcl

Selective inhibitor of the neuronal reuptake of catecholamines (noradrenaline and dopamine). It is used as an antidepressant and to help stop smoking ^{(Baraona 2017)}. Administered orally, one daily dose.

Although the concentration in milk is much higher than the plasma concentration, it is excreted in breast milk in very small amounts. ^{(Neuman 2014, Davis 2009, Haas 2004, Briggs 1993)}

The plasma levels of infants whose mothers were taking it were undetectable or very low. ^{(Neuman 2014, Davis 2009, Baab 2002, Briggs 1993)}

Given the negligible excretion in milk, the absence of plasma levels in infants and the fact that no problems were observed in infants in several publications ^{(Nonacs 2005, Baab 2002, Briggs 1993)}, two cases of seizures in infants whose mothers were taking bupropion are difficult to explain, whether in monotherapy ^{(Chaudron 2004)} or associated with other antidepressants ^{(Neuman 2014)}. Progress was satisfactory.

Bupropion does not alter prolactin levels. ^{(Whiteman 1982)}. A case of galactorrhea has been published.^{(Çam 2015)}

Avoid in mothers with a history of epilepsy since it decreases the seizure threshold.

Several experts consider the use of this medication probably safe during breastfeeding. ^{(Hale, Lactmed, Uguz 2021)}

Until there is more published data on this drug in relation to breastfeeding, safer alternatives known may be preferable ^{(Sriraman 2015, Carson 2013, Berle 2011, Davanzo 2011}), especially during the neonatal period and in case of prematurity.

See below the information of these related products:

• Maternal Depression (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
• Tobacco (Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.)