Last update Aug. 21, 2021
Very Low Risk
SSRI antidepressant with actions and uses similar to those of fluoxetine.
Oral administration once a day.
It is excreted in nil or tiny amounts into breast milk (Schoretsanitis 2019, Pogliani 2019, Weisskopf 2017, Salazar 2016, Weissman 2004, Berle 2004, Stowe 2003 y 1997, Hendrick 2001, Dodd 2000, Kristensen 1998, Altshuler 1995).
Serum levels of breastfed infants whose mothers are on Sertraline are usually undetectable or very low (Wisner 2006, Stowe 2003 & 1997, Hendrick 2001, Dodd 2001, Epperson 2001 & 1997, Wisner 1998, Kristensen 1998, Mammen 1997, Altshuler 1995).
No harm effect has been observed on health and short or long term development of infants (Pogliani 2019, Stowe 2003 & 1997, Hendrick 2003 & 2001, Kristensen 1998, Mammen 1997, Altshuler 1995).
Transient troubles in the early neonatal period like drug withdrawal syndrome or a hyperstimulation of serotonin, among newborn or premature infants with high serum levels as a result of treatment with Sertraline to the mother during pregnancy have been observed (Müller 2013, Hale 2010).
Although less commonly than other antidepressants, sertraline can cause galactorrhea (Nebhinani 2013, Lesaca 1996), with (Petit 2003) or without (Trenque 2011, Sagud 2002, Gordon 1998) hyperprolactinaemia. There may also be a transient decrease in milk production that improves with good hydration (Holland 2000).
It is probably the safest antidepressant medication while breastfeeding.
Several medical societies, experts and expert consensus, consider the use of this medication safe or probably safe during breastfeeding (Hale, LactMed, Uguz 2021, Molenaar 2018, Mcallister 2017, Pinheiro 2015, Sriraman 2015, Orsolini 2015, Davanzo 2014 & 2011, Rowe 2013, Berle 2011, Patil 2011, Amir 2011, Lanza 2009, ABM 2008, Gentile 2005, Weissman 2004, Rubin 2004, Gjerdingen 2003, Wisner 2002 & 1996, Nordeng 2001).
Women suffering from depression during pregnancy need more breastfeeding support due to their increased risk of breastfeeding problems and early weaning (Grzeskowiak 2018, Leggett 2017, Gorman 2012).
We do not have alternatives for Sertraline Hydrochloride since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.
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