Last update March 4, 2022
Very Low Risk
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Metformin Hydrochloride in other languages or writings:
Metformin Hydrochloride belongs to this group or family:
Main tradenames from several countries containing Metformin Hydrochloride in its composition:
|Oral Bioavail.||50 - 60||%|
|VD||0.9 - 3.9||l/Kg|
|M/P ratio||0.4 - 0.6||-|
|Theoretical Dose||0.02 - 0.06||mg/Kg/d|
|Relative Dose||0.11 - 0.65||%|
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e-lactancia is a resource recommended by Asociación Pro Lactancia Materna (APROLAM) of Mexico
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Oral antidiabetic biguanide medication used for treatment of Diabetes Type II, Obesity and Polycystic Ovarian Syndrome (PCOS). Oral administration one to three times daily. Biguanide drugs act by decreasing Neoglycogenesis (new formation of sugar) in the liver. Metformin does not cause hypoglycaemia. (Dashora 2022 y 2018).
Metformin is excreted into breast milk in non-significant amount. (Eyal 2010, Gardiner 2008, Briggs 2005, Hale 2004, Gardiner 2003, Hale 2002)
No problems have been observed in infants whose mothers have taken it. (Glueck 2007 & 2006, Briggs 2005, Hale 2004 & 2002, Gardiner 2003)
Plasma levels in infants were very low or undetectable. (Hale 2004 & 2002, Gardiner 2003)
Evidence for its efficacy as a galactogogue is insufficient. (Grzeskowiak 2019, Nommsen 2019))
Several medical societies, experts and expert consensus, consider the use of this medication to be safe during breastfeeding. (Philips 2021, Dashora 2018, Anderson 2018, Priya 2018, Serrano 2015, Rowe 2013, Refuerzo 2011, Amir 2011, Glatstein 2009, Feig 2007, Glueck 2006, Nice 2004)
Obesity is associated with breastfeeding difficulties. In spite of Metformin has beneficial effect on Obesity, this is not true with PCOS because lactation capacity is related to growth of breast tissue during pregnancy which is not improved by the use of Metformin. (Vanky 2012)
Oral antidiabetic drugs are not effective for Diabetes Type I. For Diabetes Type II diet, physical exercise and breastfeeding may ameliorate glycemia levels.
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