Last update Aug. 23, 2021

Secobarbital Sodium

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Barbiturate with hypnotic and sedative properties similar to amobarbital.
It has been used in insomnia and as a preanesthetic medication. Its use has been replaced by other drugs with less risk of abuse/dependence, overdose and withdrawal syndrome (Suddock 2020).
Oral or parenteral administration.

At the date of the last update, there was no available published data on its excretion in breast milk.

Its pharmacokinetic data (low molecular weight, low protein binding, prolonged half-life) make it probable that it will pass into breast milk in an amount that could be significant. On the other hand, its large volume of distribution (Breimer 1977) makes its excretion in breast milk difficult.

Product marketed in few countries.

Until more published data on this drug is available in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

  • Clotiazepam (Safe substance and/or breastfeeding is the best option.)
  • Dexmedetomidine Hydrochloride (Safe substance and/or breastfeeding is the best option.)
  • Etomidate (Safe substance and/or breastfeeding is the best option.)
  • Lorazepam (Safe substance and/or breastfeeding is the best option.)
  • Methohexital (Safe substance and/or breastfeeding is the best option.)
  • Zaleplon (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Zolpidem Tartrate (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Secobarbital Sodium is also known as


Secobarbital Sodium in other languages or writings:

Groups

Secobarbital Sodium belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Secobarbital Sodium in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 260 daltons
Protein Binding 30 - 45 %
VD 1.52 l/Kg
pKa 8.48 -
Tmax 2 - 4 hours
25 (19 - 34) hours

References

  1. Suddock JT, Cain MD. Barbiturate Toxicity. 2020 Jul 2. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Abstract
  2. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  3. Wilson JT, Brown RD, Cherek DR, Dailey JW, Hilman B, Jobe PC, Manno BR, Manno JE, Redetzki HM, Stewart JJ. Drug excretion in human breast milk: principles, pharmacokinetics and projected consequences. Clin Pharmacokinet. 1980 Jan-Feb;5(1):1-66. Review. Abstract
  4. Breimer DD. Clinical pharmacokinetics of hypnotics. Clin Pharmacokinet. 1977 Mar-Apr;2(2):93-109. Review. No abstract available. Abstract

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