Last update May 19, 2021

Etomidate

Compatible

Safe substance and/or breastfeeding is the best option.

Anesthetic indicated for the induction of general anesthesia in adults, infants and babies older than 6 months, children and adolescents (Braun 2020).
Intravenous administration in one to three preoperative doses.

It is excreted in human milk in a clinically non-significant amount (Esener 1992).

Its low excretion in breast milk and its rapid elimination allows breastfeeding as soon as the mother is awake, alert and able to hold her baby.

The small amount of colostrum obtained by the newborn in the first few feedings makes waiting to breastfeed after a cesarean even more superfluous.

Alternatives

  • Methohexital (Safe substance and/or breastfeeding is the best option.)
  • Propofol (Safe substance and/or breastfeeding is the best option.)
  • Thiopental Sodium (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Etomidate in other languages or writings:

Group

Etomidate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Etomidate in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 244 daltons
Protein Binding 77 %
VD 2 - 4.5 l/Kg
pKa 4.54 -
Tmax 0.12 hours
T½ 1.25 hours
M/P ratio 1.2 -
Theoretical Dose 0.002 - 0.012 mg/Kg/d
Relative Dose 0.8 - 3.96 %

References

  1. AEMPS-Braun. Etomidato. Ficha técnica. 2020 Full text (in our servers)
  2. SteriMax. Etomidate. Drug Summary. 2020 Full text (in our servers)
  3. Esener Z, Sarihasan B, Güven H, Ustün E. Thiopentone and etomidate concentrations in maternal and umbilical plasma, and in colostrum. Br J Anaesth. 1992 Dec;69(6):586-8. Abstract Full text (link to original source) Full text (in our servers)

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