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Zaleplon is a pyrazolopyrimidine with sedative properties similar to benzodiazepines. It is used as a hypnotic in the treatment of insomnia Oral administration at bedtime.
It is excreted in non-significant clinical amount into breast milk. (Darwish 1999)
Foods with high fat content (e.g, breast milk) delay absorption by the gut. Its low oral bioavailability decreases the pass of it from the mother's milk to the infant's plasma, except in prematures or in the early neonatal period, when a higher intestinal absorption may occur.
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Uguz 2021), especially during the neonatal period and in the event of prematurity.
It is recommended to check for sedation and/or lack of appetite in infants. Bed-sharing (co-sleeping) with the baby is not recommended if this drug are used. (ABM 2020 y 2008, UNICEF 2018, 2017, 2014 y 2013, Landa 2012, UNICEF 2006)
It has been withdrawn from the market in several countries.