Last update Aug. 23, 2021

Secbutabarbital Sodium

High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

Barbiturate with hypnotic and sedative properties.
It has been used in insomnia. Its use has been replaced by other drugs with less risk of abuse/dependence, overdose and withdrawal syndrome (Suddock 2020).
Oral administration.

At the date of the last update, there was no available published data on its excretion in breast milk.

Product with very few bibliographic references and marketed in few countries.

Until more published data on this drug is known in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

  • Clotiazepam ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Lorazepam ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Zaleplon (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Zolpidem Tartrate ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Secbutabarbital Sodium is also known as


Secbutabarbital Sodium in other languages or writings:

Groups

Secbutabarbital Sodium belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Secbutabarbital Sodium in its composition:

  • Butibel™. Contains other elements than Secbutabarbital Sodium in its composition
  • Butisol
  • Eumidral™. Contains other elements than Secbutabarbital Sodium in its composition
  • Urelief Plus™. Contains other elements than Secbutabarbital Sodium in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 234 daltons
pKa 8.48 -
Tmax 3 - 4 hours
100 hours

References

  1. Suddock JT, Cain MD. Barbiturate Toxicity. 2020 Jul 2. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Abstract
  2. Wilson JT, Brown RD, Cherek DR, Dailey JW, Hilman B, Jobe PC, Manno BR, Manno JE, Redetzki HM, Stewart JJ. Drug excretion in human breast milk: principles, pharmacokinetics and projected consequences. Clin Pharmacokinet. 1980 Jan-Feb;5(1):1-66. Review. Abstract
  3. Breimer DD. Clinical pharmacokinetics of hypnotics. Clin Pharmacokinet. 1977 Mar-Apr;2(2):93-109. Review. No abstract available. Abstract

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