Last update Aug. 23, 2021

Butabarbitone; Secbutobarbitone Sodium

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Barbiturate with hypnotic and sedative properties.
It has been used in insomnia. Its use has been replaced by other drugs with less risk of abuse/dependence, overdose and withdrawal syndrome (Suddock 2020).
Oral administration.

At the date of the last update, there was no available published data on its excretion in breast milk.

Product with very few bibliographic references and marketed in few countries.

Until more published data on this drug is known in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

  • Clotiazepam (Safe substance and/or breastfeeding is the best option.)
  • Lorazepam (Safe substance and/or breastfeeding is the best option.)
  • Zaleplon (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Zolpidem Tartrate (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Butabarbitone; Secbutobarbitone Sodium is also known as Secbutabarbital Sodium. Here it is a list of alternative known names::


Butabarbitone; Secbutobarbitone Sodium in other languages or writings:

Groups

Butabarbitone; Secbutobarbitone Sodium belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Butabarbitone; Secbutobarbitone Sodium in its composition:

  • Butibel™. Contains other elements than Butabarbitone; Secbutobarbitone Sodium in its composition
  • Butisol™
  • Eumidral™. Contains other elements than Butabarbitone; Secbutobarbitone Sodium in its composition
  • Urelief Plus™. Contains other elements than Butabarbitone; Secbutobarbitone Sodium in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 234 daltons
pKa 8.48 -
Tmax 3 - 4 hours
T½ 100 hours

References

  1. Suddock JT, Cain MD. Barbiturate Toxicity. 2020 Jul 2. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Abstract
  2. Wilson JT, Brown RD, Cherek DR, Dailey JW, Hilman B, Jobe PC, Manno BR, Manno JE, Redetzki HM, Stewart JJ. Drug excretion in human breast milk: principles, pharmacokinetics and projected consequences. Clin Pharmacokinet. 1980 Jan-Feb;5(1):1-66. Review. Abstract
  3. Breimer DD. Clinical pharmacokinetics of hypnotics. Clin Pharmacokinet. 1977 Mar-Apr;2(2):93-109. Review. No abstract available. Abstract

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