Last update April 27, 2024

Probucol

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Reduces blood cholesterol levels by mechanisms that are not well understood. It reduces cholesterol levels by increasing LDL (low density lipoprotein) degradation and can inhibit cholesterol synthesis and delay its absorption. It accumulates for long periods in fatty tissues and has a very slow elimination through the biliary tract. 

At the time of the last update, we did not find published data in relation to lactation. 

The lack of known pharmacokinetic data does not allow predicting its possible excretion in breast milk.

Due to the superior effectiveness of statins, it has been withdrawn from the market in many countries. 

Until more data are known regarding lactation, it is prudent to avoid their use at least while breast-feeding is exclusive. 

It is advisable to follow a lipid-lowering diet and to engage in regular daily physical activity, at least half an hour daily.

For considerations on the appropriateness of lipid-lowering therapy during lactation see Maternal hyperlipidemia, hypercholesterolemia, hypertriglyceridemia.


See below the information of this related product:

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Probucol in other languages or writings:

Tradenames

Main tradenames from several countries containing Probucol in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. < 10 %
Molecular weight 517 daltons
Tmax 1.200 hours
12 - 500 hours

References

  1. Probucol Drugs.com 1998 Full text (in our servers)

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