Last update Sept. 22, 2017
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Ezetimibe belongs to this group or family:
Main tradenames from several countries containing Ezetimibe in its composition:
|Oral Bioavail.||35 - 60||%|
|Protein Binding||92 - 100||%|
|Tmax||1 - 12||hours|
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e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana of Spain
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Reduces intestinal absorption of cholesterol and phytosterols (AEMPS 2016, Merck 2007).
Since the last update we have not found published data in relation to breastfeeding.
Its high binding to plasma proteins makes it unlikely it will pass into breast milk.
Cholesterol levels in milk are very stable even in hypercholesterolemic women and are not severely affected by diet or nutritional status of the mother, suggesting that 3 is synthesized, at least in part, in the mammary gland (Lawrence 2016, p 289-90).
It is not probable therefore, but it is not known if Ezetimibe is able to alter the lipid composition of the milk.
Infants need to ingest large amounts of cholesterol, as it is critical to the proper development of the nervous system, cell membranes and is a precursor of several hormones and vitamins.
Until there is more data in relation to breastfeeding, it is prudent to avoid using it, at least while breastfeeding exclusively. Suspending the pharmacological treatment of hyperlipidemia during breastfeeding is not likely to alter the long-term outcome of the disease, especially when breastfeeding can be considered therapeutic (Lawrence 2016, p.393).
It is advisable to follow a lipid-lowering diet.