Last update June 11, 2018

Colesevelam Hydrochloride

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Resina-polímero que disminuye la absorción intestinal de ácidos biliares y colesterol.
Administración oral una o dos veces al día.

A fecha de última actualización no encontramos datos publicados en relación con la lactancia.

La absorción intestinal del fármaco es nula (EMA 2017, Heller 2002, Steinmetz 2002), por lo que ni puede pasar a leche materna, ni pasaría a plasma del lactante a partir de la leche materna ingerida.

Es poco probable que pueda alterar la composición lipídica de la leche. Los lactantes necesitan ingerir cantidades elevadas de colesterol, ya que es fundamental para el correcto desarrollo del sistema nervioso, de las membranas celulares y es precursor de varias hormonas y vitaminas.

Parece interferir menos que otras resinas hipolipemiantes con la absorción de vitaminas liposolubles (A, D, E, K).

Diversos expertos consideran probablemente seguro el uso de esta medicación durante la lactancia (Hale 2017 p232, Briggs 2015).

Conviene seguir una dieta hipolipemiante.
Suspender el tratamiento farmacológico de la hipercolesterolemia durante el periodo de lactancia no es probable que altere significativamente el resultado a largo plazo de la enfermedad.

Alternatives

  • Colestipol ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Colestyramine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Colesevelam Hydrochloride in other languages or writings:

Group

Colesevelam Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Colesevelam Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0.05 %

References

  1. EMA. Colesevelam. Drug Summary. 2017 Full text (in our servers)
  2. EMA. Colesevelam. Ficha técnica. 2017 Full text (in our servers)
  3. Hale TW, Rowe HE. Medications & Mothers' Milk. A Manual of Lactation Pharmacology. Springer Publishing Company. 2017
  4. Lawrence RA, Lawrence RM. Breastfeeding. A guide for the medical profession. Eighth Edition. Philadelphia: Elsevier; 2016
  5. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  6. Heller DP, Burke SK, Davidson DM, Donovan JM. Absorption of colesevelam hydrochloride in healthy volunteers. Ann Pharmacother. 2002 Abstract
  7. Steinmetz KL. Colesevelam hydrochloride. Am J Health Syst Pharm. 2002 Abstract

Total visits

9,219

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Confederación Nacional de Pediatría (CONAPEME) of Mexico

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM