Last update April 15, 2024

Colestyramine

Compatible

Safe substance and/or breastfeeding is the best option.

Cholestyramine is a bile acid binding resin with which it forms an insoluble complex that is excreted in the feces. It prevents the normal reabsorption of bile acids and forces the liver to produce more bile, thus reducing the body's cholesterol levels (especially LDL), since cholesterol is a major component of bile. Oral administration twice a day.

At the time of the last update, we found no published data on breastfeeding.

The intestinal absorption of the drug is null (AEMPS 2013, New Zealand Data Sheet 2010), so it cannot pass into breast milk, nor would it pass into the infant's plasma from ingested breast milk.

In addition, its high molecular weight makes it very unlikely to pass into breast milk in significant quantities.

Its prolonged use can cause plasma deficiency, due to lack of absorption, of fat-soluble vitamins (A, D, E, K), so it may be advisable to supplement to avoid deficiency of these vitamins in breast milk.

Several medical societies, experts and expert consensus consider safe the use of this medication during breastfeeding (Hale, LactMed, Lawrence 2016 p393, Serrano 2015, Briggs 2015, Heetun 2007, Mahadevan 2006).

It is advisable to follow a lipid-lowering diet and engage in regular physical activity daily, at least half an hour daily.

For considerations on the appropriateness of lipid-lowering treatment during breastfeeding see Maternal hyperlipidemia, hypercholesterolemia, hypertriglyceridemia.


See below the information of this related product:

Alternatives

We do not have alternatives for Colestyramine since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Colestyramine is also known as


Colestyramine in other languages or writings:

Group

Colestyramine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Colestyramine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight > 1.000.000 daltons
0.1 hours

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Lawrence RA, Lawrence RM. Breastfeeding. A guide for the medical profession. Eighth Edition. Philadelphia: Elsevier; 2016
  4. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  5. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015 Jan 20;144(2):73-9. Abstract
  6. AEMPS. Colestiramina. Ficha técnica. 2013 Full text (in our servers)
  7. New Zealand Data Sheet Cholestyramine Drug Summary 2010 Full text (in our servers)
  8. Heetun ZS, Byrnes C, Neary P, O'Morain C. Review article: Reproduction in the patient with inflammatory bowel disease. Aliment Pharmacol Ther. 2007 Abstract Full text (link to original source) Full text (in our servers)
  9. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)

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