Last update Dec. 10, 2022

Piperidolate Hydrochloride

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is a tertiary amine with antimuscarinic/anticholinergic effects, with an action similar to atropine. It has smooth muscle antispasmodic properties. Administered for gastroenteritis, duodenal ulcer, biliary conditions, dysmenorrhea and treatment of miscarriage and premature birth. (Kyorin 2013, Sanofi 2010)

At the date of the last update we did not find any published data on its excretion in breast milk.

There is hardly any published scientific data on this product: there are only 6 studies and the most recent dates from 1977. There is no pharmacokinetic data except that it has good absorption in the digestive tract. (Sanofi 2010)

Other anticholinergics from the same family such as tolterodine have high protein binding, which would make it unlikely that it passes into milk in significant amounts.

During breastfeeding it may be prudent to avoid or take short-term and minimal doses, monitoring milk production as anticholinergics may reduce milk production (Müller 1983, Masala 1982, De Martino 1980, Bizarro 1980), especially the first few weeks postpartum. Once lactation is established, milk production depends more on the repeated stimulation of suckling than on prolactin levels.

It is also advisable to monitor anticholinergic symptoms in the infant (dry mouth, constipation...).


  • Atropine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Otilonium Bromide (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Piperidolate Hydrochloride in other languages or writings:


Piperidolate Hydrochloride belongs to this group or family:


Main tradenames from several countries containing Piperidolate Hydrochloride in its composition:


Variable Value Unit
Molecular weight 360 daltons


  1. Kyorin. Dactiran (Piperidolate). Drug Summary. 2013 Full text (in our servers)
  2. Sanofi. Dúctil (Piperidolato). Ficha técnica. 2010 Full text (in our servers)
  3. Müller EE, Locatelli V, Cella S, Peñalva A, Novelli A, Cocchi D. Prolactin-lowering and -releasing drugs. Mechanisms of action and therapeutic applications. Drugs. 1983 Apr;25(4):399-432. Review. Abstract
  4. Masala A, Alagna S, Devilla L, Rovasio PP, Rassa S, Faedda R, Satta A. Muscarinic receptor blockade by pirenzepine: effect on prolactin secretion in man. J Endocrinol Invest. 1982 Jan-Feb;5(1):53-5. Abstract
  5. Bizzarro A, Iannucci F, Tolino A, Soricelli A, Guarino G, Verdoliva A. Inhibiting effect of atropine on prolactin blood levels after stimulation with TRH. Clin Exp Obstet Gynecol. 1980 Abstract
  6. De Martino F, De Matteo A, L'Abbate V, Soricelli A, Fontana A, Petrenga E, Cesarone M. [Inhibitory effects of atropine on serum prolactin levels after TRH stimulation]. Boll Soc Ital Biol Sper. 1980 Abstract

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America

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