Last update Feb. 1, 2017

Otilonium Bromide

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Anticholinergic drug used as spasmolytic for functional gastrointestinal disorders.

At latest update relevant published data on excretion into breast milk were not found.

It acts locally on the intestinal mucosa. Absorption through the intestine is practically absent (Evangelista 2004, Catalogo 2008), with an excretion being almost 100% unmodified in feces that is determinant for the extremely low levels reached in the plasma (Zhao 2010: <0.02 mg / L), which causes the passage through breastmilk in significant amounts must be very unlikely.
Side effects are mild and very rarely seen.

Although anticholinergics may reduce milk production, however, because of its poor absorption it would not be the case with Otilonium.


We do not have alternatives for Otilonium Bromide since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Otilonium Bromide in other languages or writings:


Otilonium Bromide belongs to this group or family:


Main tradenames from several countries containing Otilonium Bromide in its composition:


Variable Value Unit
Oral Bioavail. 3 %
Molecular weight 564 daltons
Tmax 1.5 hours


  1. AEMPS. Otilonio. Ficha técnica. 2015 Full text (in our servers)
  2. Zhao YR, Ding L, Fan HW, Yu Y, Qi XM, Leng Y, Rao YK. Determination of the unstable drug otilonium bromide in human plasma by LC-ESI-MS and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Abstract
  3. Catalioto RM, Triolo A, Giuliani S, Altamura M, Evangelista S, Maggi CA. Increased paracellular absorption by bile salts and P-glycoprotein stimulated efflux of otilonium bromide in Caco-2 cells monolayers as a model of intestinal barrier. J Pharm Sci. 2008 Abstract
  4. Evangelista S. Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome. Curr Pharm Des. 2004 Abstract

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