Last update June 23, 2022


High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

Typical, first generation antipsychotic. Prochlorperazine is a phenothiazine derivative with general properties similar to those of chlorpromazine. It has been used in the treatment of schizophrenia and other psychoses. Oral or intramuscular administration (depot).

Since the last update we have not found published data on its excretion in breastmilk.

Product with very few bibliographic references, without known pharmacokinetic data and marketed in few countries.

Known safer alternatives are preferable (Parikh 2014), especially during the neonatal period and in the event of prematurity.

It has been withdrawn from the market in many countries. (Mustafa 2017)

See below the information of this related product:


  • Chlorpromazine (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Olanzapine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Perphenazine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Trifluoperazine Hydrochloride ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.


N05AC04 belongs to these groups or families:


Main tradenames from several countries containing N05AC04 in its composition:


Variable Value Unit
Molecular weight 458 daltons


  1. Mustafa FA. Switching away from pipotiazine palmitate: a naturalistic study. Ther Adv Psychopharmacol. 2017 Jan;7(1):25-28. Abstract
  2. Parikh T, Goyal D, Scarff JR, Lippmann S. Antipsychotic drugs and safety concerns for breast-feeding infants. South Med J. 2014 Abstract

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