Last update June 23, 2022

Pipotiazine Palmitate

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Typical, first generation antipsychotic. Prochlorperazine is a phenothiazine derivative with general properties similar to those of chlorpromazine. It has been used in the treatment of schizophrenia and other psychoses. Oral or intramuscular administration (depot).

Since the last update we have not found published data on its excretion in breastmilk.

Product with very few bibliographic references, without known pharmacokinetic data and marketed in few countries.

Known safer alternatives are preferable (Parikh 2014), especially during the neonatal period and in the event of prematurity.

It has been withdrawn from the market in many countries. (Mustafa 2017)


See below the information of this related product:

Alternatives

  • Chlorpromazine (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Olanzapine (Safe substance and/or breastfeeding is the best option.)
  • Perphenazine (Safe substance and/or breastfeeding is the best option.)
  • Trifluoperazine Hydrochloride (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Pipotiazine Palmitate is also known as Pipotiazine.


Pipotiazine Palmitate in other languages or writings:

Groups

Pipotiazine Palmitate belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Pipotiazine Palmitate in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 458 daltons

References

  1. Mustafa FA. Switching away from pipotiazine palmitate: a naturalistic study. Ther Adv Psychopharmacol. 2017 Jan;7(1):25-28. Abstract
  2. Parikh T, Goyal D, Scarff JR, Lippmann S. Antipsychotic drugs and safety concerns for breast-feeding infants. South Med J. 2014 Abstract

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