Last update June 23, 2022
Very Low Risk
Typical, first generation antipsychotic. Perphenazine is a piperazine phenothiazine derivative similar to chlorpromazine with antipsychotic, antiemetic and weak sedative activity with properties. It is used in the treatment of schizophrenia, mania/bipolar disorder, behavioral disorders, anxiety, post-operative or post-chemotherapy nausea and vomiting, and intractable hiccups. Oral administration in three daily doses.
It is excreted in breast milk in clinically insignificant amounts and no problems were seen in an infant whose mother was taking it. (Olesen 1990)
It can cause hyperprolactinemia and galactorrhea. (Canuso 1998, Musey 1986, Basler 1985, Lindholm 1978)
Expert authors consider the use of this medication possibly safe during lactation. (Niforatos 2019, Parikh 2014, Rubin 2004, Winans 2001)
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Kronenfeld 2017, Parikh 2014, Klinger 2013, Pons 1994), especially during the neonatal period and in the event of prematurity.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.
e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM