Last update Aug. 23, 2021

Amobarbital Sodium

High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

Barbiturate with hypnotic and sedative properties.
It has been used in the treatment of insomnia, epileptic seizures and as a preanesthetic medication.
Its use has been replaced by other drugs with less risk of abuse/dependence, overdose and withdrawal syndrome (Suddock 2020).
Oral or parenteral administration.

At the date of the last update, there was no available published data on its excretion in breast milk.

Its pharmacokinetic data (low molecular weight, low protein binding and prolonged elimination) make it likely to pass into breast milk in an amount that could be significant.

Product marketed in very few countries.

Until more published data on this drug is known in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in the event of prematurity

Alternatives

  • Clotiazepam ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Dexmedetomidine Hydrochloride ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Etomidate ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Lorazepam ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Methohexital ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Zaleplon (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Zolpidem Tartrate ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Amobarbital Sodium is also known as


Amobarbital Sodium in other languages or writings:

Groups

Amobarbital Sodium belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Amobarbital Sodium in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 248 daltons
Protein Binding 60 %
pKa 8.48 -
20 - 25 hours

References

  1. Suddock JT, Cain MD. Barbiturate Toxicity. 2020 Jul 2. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Abstract

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