Last update Jan. 6, 2022

塩酸メクロレタミン

Very High Risk

Very unsafe. Contraindicated. Use of an alternative or cessation of breastfeeding. Read the Comment.

Agente alquilante con propiedades inmunosupresoras. Utilizado de forma sistémica (administración intravenosa) en ciertos cánceres y de forma tópica (gel) en algunos linfomas cutáneos de células T, como la micosis fungoide. 

A fecha de última actualización no encontramos datos publicados sobre su excreción en leche materna.

La ausencia de datos de farmacocinética de este producto no permite predecir su posible excreción en leche materna, por lo que, dada su gran toxicidad, la administración sistémica está completamente contraindicada durante la lactancia.

ADMINISTRACIÓN TÓPICA:

La absorción sistémica de este producto a través de la piel es nula, no detectándose niveles plasmáticos tras su aplicación cutánea prolongada (Querfeld 2021, Recordati 2021), por lo que la administración tópica sería compatible con la lactancia, a condición de no aplicar sobre el pecho y evitar cuidadosamente cualquier contacto del producto con el lactante. 

Alternatives

We do not have alternatives for 塩酸メクロレタミン.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

塩酸メクロレタミン is Chlormethine Hydrochloride in Japanese.

Is written in other languages:

塩酸メクロレタミン is also known as

Groups

塩酸メクロレタミン belongs to these groups or families:

Tradenames

Main tradenames from several countries containing 塩酸メクロレタミン in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 193 daltons

References

  1. Recordati. Chlormethine Gel (LEDAGA). Drug Summary. 2021 Full text (in our servers)
  2. Querfeld C, Geskin LJ, Kim EJ, Scarisbrick JJ, Quaglino P, Papadavid E, Angello JT, Ortiz-Romero PL. Lack of Systemic Absorption of Topical Mechlorethamine Gel in Patients with Mycosis Fungoides Cutaneous T-Cell Lymphoma. J Invest Dermatol. 2021 Jun;141(6):1601-1604.e2. Abstract

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