Last update Jan. 6, 2022

Хлорметина Гидрохлорид

Very High Risk

Very unsafe. Contraindicated. Use of an alternative or cessation of breastfeeding. Read the Comment.

Agente alquilante con propiedades inmunosupresoras. Utilizado de forma sistémica (administración intravenosa) en ciertos cánceres y de forma tópica (gel) en algunos linfomas cutáneos de células T, como la micosis fungoide. 

A fecha de última actualización no encontramos datos publicados sobre su excreción en leche materna.

La ausencia de datos de farmacocinética de este producto no permite predecir su posible excreción en leche materna, por lo que, dada su gran toxicidad, la administración sistémica está completamente contraindicada durante la lactancia.


La absorción sistémica de este producto a través de la piel es nula, no detectándose niveles plasmáticos tras su aplicación cutánea prolongada (Querfeld 2021, Recordati 2021), por lo que la administración tópica sería compatible con la lactancia, a condición de no aplicar sobre el pecho y evitar cuidadosamente cualquier contacto del producto con el lactante. 


We do not have alternatives for Хлорметина Гидрохлорид.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Хлорметина Гидрохлорид is Chlormethine Hydrochloride in Cyrillic.

Is written in other languages:

Хлорметина Гидрохлорид is also known as


Хлорметина Гидрохлорид belongs to these groups or families:


Main tradenames from several countries containing Хлорметина Гидрохлорид in its composition:


Variable Value Unit
Molecular weight 193 daltons


  1. Querfeld C, Geskin LJ, Kim EJ, Scarisbrick JJ, Quaglino P, Papadavid E, Angello JT, Ortiz-Romero PL. Lack of Systemic Absorption of Topical Mechlorethamine Gel in Patients with Mycosis Fungoides Cutaneous T-Cell Lymphoma. J Invest Dermatol. 2021 Jun;141(6):1601-1604.e2. Abstract
  2. Recordati. Chlormethine Gel (LEDAGA). Drug Summary. 2021 Full text (in our servers)

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