Last update Sept. 23, 2023

Trientine Dihydrochloride


Safe substance and/or breastfeeding is the best option.

Copper chelator used in the treatment of Wilson's disease.

It is excreted in breast milk in no or no detectable amount (Kodama 2021, Izumi 2012), and no clinical or analytical problems (Cu, Zn) have been observed in infants whose mothers took it. (Shiga 2006, Kodama 2021, Reuner 2019)

Copper and zinc levels in breastmilk of mothers treated with penicillamine, trientine or zinc are normal. (Kodama 2021)

Oral bioavailability, which is very low during periods of fasting, is practically non-existent in the presence of food, especially milk, so it would be very difficult to pass into the infant plasma from the ingested breast milk (PDR 2016).


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Trientine Dihydrochloride is also known as

Trientine Dihydrochloride in other languages or writings:


Trientine Dihydrochloride belongs to this group or family:


Main tradenames from several countries containing Trientine Dihydrochloride in its composition:


Variable Value Unit
Oral Bioavail. 6 - 18 %
Molecular weight 219 daltons
Tmax 2 hours
2 - 4 hours


  1. Kodama H, Anan Y, Izumi Y, Sato Y, Ogra Y. Copper and zinc concentrations in the breast milk of mothers undergoing treatment for Wilson's disease: a prospective study. BMJ Paediatr Open. 2021 Jun 17;5(1):e000948. Abstract
  2. Reuner U, Dinger J. Pregnancy and Wilson disease: management and outcome of mother and newborns-experiences of a perinatal centre. Ann Transl Med. 2019 Apr;7(Suppl 2):S56. Abstract
  3. PDR. Trientine hydrochloride. Drug Summary. 2016 Full text (link to original source) Full text (in our servers)
  4. Izumi Y. Can mothers with Wilson's disease give her breast milk to their infant? Teikyo Med J. 2012;35:17-24. 2012 Full text (link to original source) Full text (in our servers)
  5. Shiga K, Kaga H, Kodama H, Fujisawa C, Gu YH, Tamai H, Shimizu N. Copper and zinc concentrations in the breast milk of mothers with Wilson disease and e¡ects on infants. J Inherit Metab Dis (2006) 29 (Suppl 1). P-12-3 Full text (in our servers)

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