Last update Sept. 25, 2023

Zinc (systemic administration)

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Zinc in systemic administration (oral or intravenous)

Zinc is used to treat zinc deficiency, Wilson's disease and acrodermatitis enteropathica. In deficiency states and acrodermatitis, zinc sulfate, gluconate or citrate (less frequently zinc oxide) are used orally, and zinc chloride or zinc sulfate are used intravenously. For Wilson's disease, zinc acetate is used orally as an inhibitor of copper absorption.

Zinc (Zn) is an essential element of nutrition. It is present in many foods. The daily needs of Zn are 8 to 15 mg (Hall Moran 2010) and depend on the daily intake of phytates. In nursing mothers they are 11 mg for low intakes of phytate (≤ 330 mg/day) and 14 mg/day for high intakes (≥ 990 mg/day) of phytate. (Haase 2020)

The average concentration of Zn in colostrum is 4 to 10 mg/L, subsequently decreasing to 1 - 2 mg/L in mature milk, and is higher in cases of prematurity (Lastre 2020, Trinta 2020, Suarez 2019, Dórea 2012, Hannan 2005, Picciano 1976) and is independent of plasma levels and daily maternal intake (Hannan 2009, Chierici 1999, Krebs 1995, Moser 1990), even with high doses of zinc used in Wilson's disease. (Isagawa 2020)

Zn intervenes in the process of regulation of lactation (Lee 2016). Pasteurization of breast milk does not affect the concentration of Zn or other trace elements. (Mohd-Taufek 2016)

The intestinal absorption of zinc almost doubles during pregnancy and lactation. (Fung 1997).

Infant zinc levels depend on zinc levels in breast milk. (Dumrongwongsiri 2015)

With a varied and balanced diet, mineral supplements are not necessary. Excess ingestion of zinc can lead to gastric, intestinal and pancytopenia problems. (Irving 2003)


See below the information of these related products:

  • Fytate; Phytate (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Resorcinol (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Zinc (topical administration) ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Zinc (systemic administration) is also known as


Zinc (systemic administration) in other languages or writings:

Tradenames

Main tradenames from several countries containing Zinc (systemic administration) in its composition:

  • 102 Plus™. Contains other elements than Zinc (systemic administration) in its composition
  • Antioxidant Formula™. Contains other elements than Zinc (systemic administration) in its composition
  • Briovital Glucobefol™. Contains other elements than Zinc (systemic administration) in its composition
  • Broken™. Contains other elements than Zinc (systemic administration) in its composition
  • Caladryl Clear™. Contains other elements than Zinc (systemic administration) in its composition
  • Cicalfate™. Contains other elements than Zinc (systemic administration) in its composition
  • Cicaplast (Mexico)™. Contains other elements than Zinc (systemic administration) in its composition
  • Cicaplast (France)™. Contains other elements than Zinc (systemic administration) in its composition
  • Cicaplast (Ireland)™. Contains other elements than Zinc (systemic administration) in its composition
  • Cicaplast (Chile)™. Contains other elements than Zinc (systemic administration) in its composition
  • Copinal
  • Cro-Man-Zin™. Contains other elements than Zinc (systemic administration) in its composition
  • Defend & Resist™. Contains other elements than Zinc (systemic administration) in its composition
  • Elevit™. Contains other elements than Zinc (systemic administration) in its composition
  • Full Motion™. Contains other elements than Zinc (systemic administration) in its composition
  • NCZ (India)™. Contains other elements than Zinc (systemic administration) in its composition
  • Ocuclear (India)™. Contains other elements than Zinc (systemic administration) in its composition
  • Ostron™. Contains other elements than Zinc (systemic administration) in its composition
  • Pharmaton Matruelle™. Contains other elements than Zinc (systemic administration) in its composition
  • Pilopeptan Woman comprimidos™. Contains other elements than Zinc (systemic administration) in its composition
  • Seidibion Embarazo™. Contains other elements than Zinc (systemic administration) in its composition
  • Seidibion Mater preparto, posparto y lactancia™. Contains other elements than Zinc (systemic administration) in its composition
  • Seidibion Prime Embarazo™. Contains other elements than Zinc (systemic administration) in its composition
  • Seidylevur adultos™. Contains other elements than Zinc (systemic administration) in its composition
  • Senexon Plus™. Contains other elements than Zinc (systemic administration) in its composition
  • Soyaloid Apruri™. Contains other elements than Zinc (systemic administration) in its composition
  • Supradyn Forte™. Contains other elements than Zinc (systemic administration) in its composition
  • Supradyn Prenatal™. Contains other elements than Zinc (systemic administration) in its composition
  • Supradyn Pronatal™. Contains other elements than Zinc (systemic administration) in its composition
  • Tonovital Plus Antioxidante™. Contains other elements than Zinc (systemic administration) in its composition
  • Udamin™. Contains other elements than Zinc (systemic administration) in its composition
  • Vitene Antiage™. Contains other elements than Zinc (systemic administration) in its composition
  • Wilzin
  • Zincaps

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 20 - 30 %
Molecular weight 65 daltons
Theoretical Dose 0.0004 mg/Kg/d
Relative Dose 0.12 %

References

  1. Keikha M, Shayan-Moghadam R, Bahreynian M, Kelishadi R. Nutritional supplements and mother's milk composition: a systematic review of interventional studies. Int Breastfeed J. 2021 Jan 4;16(1):1. Abstract Full text (link to original source)
  2. Trinta VO, Padilha PC, Petronilho S, Santelli RE, Braz BF, Freire AS, Saunders C, Rocha HFD, Sanz-Medel A, Fernández-Sánchez ML. Total metal content and chemical speciation analysis of iron, copper, zinc and iodine in human breast milk using high-performance liquid chromatography separation and inductively coupled plasma mass spectrometry detection. Food Chem. 2020 Oct 1;326:126978. Abstract Full text (link to original source)
  3. Isagawa S, Shiohira H, Hokama N, Nitta H, Yoshida T, Masamoto H, Aoki Y, Nakamura K. Measurement of zinc concentration in blood and breast milk of a Wilson's disease patient taking zinc acetate. Pharmazie. 2020 May 1;75(5):177-178. Abstract Full text (link to original source)
  4. Haase H, Ellinger S, Linseisen J, Neuhäuser-Berthold M, Richter M; German Nutrition Society (DGE).. Revised D-A-CH-reference values for the intake of zinc. J Trace Elem Med Biol. 2020 Apr 23;61:126536. Abstract Full text (link to original source)
  5. Lastre-Amell G, Carrero González CM, Delgado Diloreto FB, Suarez-Villa M, Granadillo Morán V, Orostegui Santander MA. Concentraciones de los oligoelementos cobre y zinc en leche materna, de vaca y de cabra. [Concentrations of trace elements like copper and zinc in breast, cow's and goat's milk]. Rev Cubana Pediatr vol.92 no.2 Ciudad de la Habana abr.-jun. 2020 Epub 15-Abr-2020 Full text (link to original source)
  6. Suarez-Villa M, Carrero C, Granadillo V, Lastre-Amell G, Orostegui MA, Delgado F. Niveles de cobre y zinc en diferentes etapas de la leche materna y la influencia del estado nutricional de madres lactantes. [Levels of copper and zinc in different stages of breast milk and the influence of the nutritional state of nursing mothers]. Rev. chil. nutr. vol.46 no.5 Santiago oct. 2019 Full text (link to original source)
  7. Gibson RS, King JC, Lowe N. A Review of Dietary Zinc Recommendations. Food Nutr Bull. 2016 Abstract
  8. Abe SK, Balogun OO, Ota E, Takahashi K, Mori R. Supplementation with multiple micronutrients for breastfeeding women for improving outcomes for the mother and baby. Cochrane Database Syst Rev. 2016 Abstract Full text (link to original source)
  9. Lee S, Kelleher SL. Molecular regulation of lactation: The complex and requisite roles for zinc. Arch Biochem Biophys. 2016 Abstract
  10. Mohd-Taufek N, Cartwright D, Davies M, Hewavitharana AK, Koorts P, McConachy H, Shaw PN, Sumner R, Whitfield K. The effect of pasteurization on trace elements in donor breast milk. J Perinatol. 2016 Abstract
  11. Dumrongwongsiri O, Suthutvoravut U, Chatvutinun S, Phoonlabdacha P, Sangcakul A, Siripinyanond A, Thiengmanee U, Chongviriyaphan N. Maternal zinc status is associated with breast milk zinc concentration and zinc status in breastfed infants aged 4-6 months. Asia Pac J Clin Nutr. 2015 Abstract
  12. Ares Segura S, Arena Ansótegui J, Díaz-Gómez NM; en representación del Comité de Lactancia Materna de la Asociación Española de Pediatría. La importancia de la nutrición materna durante la lactancia, ¿necesitan las madres lactantes suplementos nutricionales? [The importance of maternal nutrition during breastfeeding: Do breastfeeding mothers need nutritional supplements?] An Pediatr (Barc). 2015 Abstract Full text (link to original source) Full text (in our servers)
  13. Severi C, Hambidge M, Krebs N, Alonso R, Atalah E. Zinc in plasma and breast milk in adolescents and adults in pregnancy and pospartum: a cohort study in Uruguay. Nutr Hosp. 2013 Abstract
  14. Izumi Y. Can mothers with Wilson's disease give her breast milk to their infant? Teikyo Med J. 2012;35:17-24. 2012 Full text (link to original source) Full text (in our servers)
  15. Dórea JG. Zinc and copper concentrations in breastmilk. Indian Pediatr. 2012 Abstract Full text (link to original source)
  16. Ejezie F, Nwagha U. Zinc Concentration during Pregnancy and Lactation in Enugu, South-East Nigeria. Ann Med Health Sci Res. 2011 Abstract
  17. Hall Moran V, Lowe N, Crossland N, Berti C, Cetin I, Hermoso M, Koletzko B, Dykes F. Nutritional requirements during lactation. Towards European alignment of reference values: the EURRECA network. Matern Child Nutr. 2010 Oct;6 Suppl 2:39-54. Abstract Full text (link to original source) Full text (in our servers)
  18. Hannan MA, Faraji B, Tanguma J, Longoria N, Rodriguez RC. Maternal milk concentration of zinc, iron, selenium, and iodine and its relationship to dietary intakes. Biol Trace Elem Res. 2009 Abstract
  19. EFSA. European Food Safety Authority. Tolerable upper intake levels for vitamins and minerals. Scientific Committee on Food. 2006 Full text (link to original source) Full text (in our servers)
  20. Hannan MA, Dogadkin NN, Ashur IA, Markus WM. Copper, selenium, and zinc concentrations in human milk during the first three weeks of lactation. Biol Trace Elem Res. 2005 Abstract
  21. Irving JA, Mattman A, Lockitch G, Farrell K, Wadsworth LD. Element of caution: a case of reversible cytopenias associated with excessive zinc supplementation. CMAJ. 2003 Abstract
  22. Institute of Medicine (US) Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press (US); 2001. Abstract Full text (link to original source)
  23. Chierici R, Saccomandi D, Vigi V. Dietary supplements for the lactating mother: influence on the trace element content of milk. Acta Paediatr Suppl. 1999 Abstract
  24. Fung EB, Ritchie LD, Woodhouse LR, Roehl R, King JC. Zinc absorption in women during pregnancy and lactation: a longitudinal study. Am J Clin Nutr. 1997 Abstract
  25. Itriago A, Carrión N, Fernández A, Puig M, Dini E. [Zinc, copper, iron, calcium, phosphorus and magnesium content of maternal milk during the first 3 weeks of lactation]. Arch Latinoam Nutr. 1997 Abstract
  26. Doran L, Evers S. Energy and nutrient inadequacies in the diets of low-income women who breast-feed. J Am Diet Assoc. 1997 Abstract
  27. Krebs NF, Reidinger CJ, Hartley S, Robertson AD, Hambidge KM. Zinc supplementation during lactation: effects on maternal status and milk zinc concentrations. Am J Clin Nutr. 1995 Abstract
  28. Moser-Veillon PB, Reynolds RD. A longitudinal study of pyridoxine and zinc supplementation of lactating women. Am J Clin Nutr. 1990 Jul;52(1):135-41. Abstract
  29. Picciano MF, Guthrie HA. Copper, iron, and zinc contents of mature human milk. Am J Clin Nutr. 1976 Abstract

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