Last update Dec. 2, 2022

Thiethylperazine Maleate

High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

1st generation antihistamine, derived from phenothiazine with sedative effect. Atypical antipsychotic of clozapine-like structure with antidopaminergic effect. Used as an antiemetic in surgical and oncological processes and in the treatment of vertigo and dizziness. Oral, rectal or intramuscular administration.

At the date of the last update, the authors did not find any published data on its excretion in breast milk.

Other phenothiazine derivatives are minimally excreted in milk, so the occasional use of thiethylperazine would be compatible with lactation. (LactMed, accessed 12/2021)

Phenothiazines can produce hyperprolactinemia, increased milk production, and galactorrhea. (Goodnick 2002, Turkington 1972)

Product with few bibliographical references and withdrawn from the market in many countries.

Alternatives

  • Cinnarizine (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Meclozine Hydrochloride (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Metoclopramide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Ondansetron ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Perphenazine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Thiethylperazine Maleate is also known as


Thiethylperazine Maleate in other languages or writings:

Groups

Thiethylperazine Maleate belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Thiethylperazine Maleate in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 632 daltons
Protein Binding 60 %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on March 15, 2022 Full text (link to original source)
  2. Goodnick PJ, Rodriguez L, Santana O. Antipsychotics: impact on prolactin levels. Expert Opin Pharmacother. 2002 Oct;3(10):1381-91. Review. Abstract
  3. Turkington RW. Prolactin secretion in patients treated with various drugs: phenothiazines, tricyclic antidepressants, reserpine, and methyldopa. Arch Intern Med. 1972 Abstract

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