Last update Dec. 24, 2021

硫乙拉嗪

High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

Antihistamínico de 1ª generación, derivado de la fenotiazina con efecto sedante. Antipsicóico atípico de estrutura similar a la clozapina con efecto antidopaminérgico. Usado como antiemetico en procesos quirúrgicos y oncológicos y en el contol de vértigo y mareos. Adminsitración oral, rectal o intramuscular.

A fecha de última actualización no encontramos datos publicados sobre su excreción en leche materna.

Otros derivados de la fenotiazina se excretan mínimamente en leche, por lo que el uso puntual de la tietilperazina sería compatible con la lactancia. (LactMed, acceso en 12/2021)

Las fenotiazinas pueden producir hiperprolactinema, aumento de la producción de leche y galatorrea. (Goodnick 2002, Turkington 1972)

Producto con escasas referencias bibliográficas y retirado del comercio en muhcos países.

Alternatives

  • Cinnarizine (Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Meclozine Hydrochloride (Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Ondansetron ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Perphenazine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Sulpiride (Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

硫乙拉嗪 is Thiethylperazine Maleate in Chinese.

Is written in other languages:

硫乙拉嗪 is also known as

Group

硫乙拉嗪 belongs to this group or family:

Tradenames

Main tradenames from several countries containing 硫乙拉嗪 in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 632 daltons
Protein Binding 60 %

References

  1. Goodnick PJ, Rodriguez L, Santana O. Antipsychotics: impact on prolactin levels. Expert Opin Pharmacother. 2002 Oct;3(10):1381-91. Review. Abstract
  2. Turkington RW. Prolactin secretion in patients treated with various drugs: phenothiazines, tricyclic antidepressants, reserpine, and methyldopa. Arch Intern Med. 1972 Abstract

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