Last update Sept. 9, 2022

أسيميتاسين

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Acemetacin, a compound of indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID). Its pharmacological activity is due to acemetacin and its main metabolite, indomethacin. It is used in rheumatoid arthritis, osteoarthritis, and low back pain, and for postoperative pain and inflammation. Oral administration in several doses per day.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data (very high percentage of protein binding, moderately high molecular weight and very wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.

The literature on this drug is very scarce.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

  • Diclofenac ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Ibuprofen ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Indomethacin; Indometacin ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

أسيميتاسين is Acemetacin in Arabic.

Is written in other languages:

Group

أسيميتاسين belongs to this group or family:

Tradenames

Main tradenames from several countries containing أسيميتاسين in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 66 %
Molecular weight 416 daltons
Protein Binding > 90 %
VD 0.5 - 0.7 l/Kg
pKa 3.26 -
Tmax 2.5 hours
4.5 hours

References

  1. DRUGBANK ONLINE. DrugBank.com 2006 - Consulted on Feb. 16, 2023 Full text (link to original source)
  2. Royal Pharmaceutical Society. Martindale: The Complete Drug Reference Medicines Complete. available online from: https://www.medicinescomplete.com 2022 Abstract
  3. INH Rafael Rangel. Acemetacina. Ficha técnica. 2020 Full text (in our servers)

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