Last update Sept. 9, 2022


Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Acemetacin, a compound of indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID). Its pharmacological activity is due to acemetacin and its main metabolite, indomethacin. It is used in rheumatoid arthritis, osteoarthritis, and low back pain, and for postoperative pain and inflammation. Oral administration in several doses per day.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data (very high percentage of protein binding, moderately high molecular weight and very wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.

The literature on this drug is very scarce.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in the event of prematurity.


  • Diclofenac (Safe substance and/or breastfeeding is the best option.)
  • Ibuprofen (Safe substance and/or breastfeeding is the best option.)
  • Indomethacin; Indometacin (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Ацеметацин is Acemetacin in Cyrillic.

Is written in other languages:


Ацеметацин belongs to this group or family:


Main tradenames from several countries containing Ацеметацин in its composition:


Variable Value Unit
Oral Bioavail. 66 %
Molecular weight 416 daltons
Protein Binding > 90 %
VD 0.5 - 0.7 l/Kg
pKa 3.26 -
Tmax 2.5 hours
4.5 hours


  1. DRUGBANK ONLINE. 2006 - Consulted on Jan. 9, 2024 Full text (link to original source)
  2. Royal Pharmaceutical Society. Martindale: The Complete Drug Reference Medicines Complete. available online from: 2022 Abstract
  3. INH Rafael Rangel. Acemetacina. Ficha técnica. 2020 Full text (in our servers)

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