Last update May 22, 2025

سيفاتريزين

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

First-generation cephalosporin antibiotic. Oral administration. Actions and uses similar to those of cefalexin.

At latest update no published data on excretion into breast milk were found.

Its moderately high molecular weight and short half-life make passage into milk of significant amounts unlikely.

Most cephalosporins are excreted into milk in insignificant amounts from a therapeutic point of view (Rowe 2013, Fulton 1992, Matsuda 1984, Kafetzis 1981) without reported complications in infants.

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Product with very few bibliographical references and marketed in few countries.

Alternatives

  • Cefadroxil (Safe product and/or breastfeeding is the best option.)
  • Ceftibuten (Safe product and/or breastfeeding is the best option.)
  • Cephalexin (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

سيفاتريزين is Cefatrizine in Arabic.

Is written in other languages:

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سيفاتريزين belongs to this group or family:

Tradenames

Main tradenames from several countries containing سيفاتريزين in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 48 - 75 %
Molecular weight 463 daltons
VD 0.22 l/Kg
pKa 7.22 -
Tmax 1.4 - 2 hours
T½ 1 - 1.7 hours

References

  1. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  2. Yu LX, Amidon GL. Saturable small intestinal drug absorption in humans: modeling and interpretation of cefatrizine data. Eur J Pharm Biopharm. 1998 Abstract
  3. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  4. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  5. Mastrandrea V, Ripa S, La Rosa F, Ghezzi A. Pharmacokinetics of cefatrizine after oral administration in human volunteers. Int J Clin Pharmacol Res. 1985 Abstract
  6. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract
  7. Pfeffer M, Gaver RC, Ximenez J. Human intravenous pharmacokinetics and absolute oral bioavailability of cefatrizine. Antimicrob Agents Chemother. 1983 Abstract
  8. Kafetzis DA, Siafas CA, Georgakopoulos PA, Papadatos CJ. Passage of cephalosporins and amoxicillin into the breast milk. Acta Paediatr Scand. 1981 Abstract

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