Last update Oct. 15, 2016

Cefatrizine Propylene Glycol

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

First-generation cephalosporins for oral administration. Actions and uses similar to those of cefalexin.

At latest update no published data on excretion into breast milk were found.

Their short half-life span make unlikely the milk passage of significant amounts into breast milk.

Most cephalosporins are excreted into milk in insignificant amounts from a therapeutic point of view without reported complications in infants.

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Alternatives

  • Cefalotin Sodium ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Cephalexin ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cefatrizine Propylene Glycol is also known as Cefatrizine.


Cefatrizine Propylene Glycol in other languages or writings:

Group

Cefatrizine Propylene Glycol belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefatrizine Propylene Glycol in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 48 - 75 %
Molecular weight 463 daltons
VD 0.22 l/Kg
Tmax 1.4 - 2 hours
1 - 1.7 hours

References

  1. Yu LX, Amidon GL. Saturable small intestinal drug absorption in humans: modeling and interpretation of cefatrizine data. Eur J Pharm Biopharm. 1998 Abstract
  2. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  3. Mastrandrea V, Ripa S, La Rosa F, Ghezzi A. Pharmacokinetics of cefatrizine after oral administration in human volunteers. Int J Clin Pharmacol Res. 1985 Abstract
  4. Pfeffer M, Gaver RC, Ximenez J. Human intravenous pharmacokinetics and absolute oral bioavailability of cefatrizine. Antimicrob Agents Chemother. 1983 Abstract

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