Last update May 23, 2025

Ceftibuten

Compatible

Safe product and/or breastfeeding is the best option.

Third generation cephalosporin antibiotic. Oral administration once daily.

Like most cephalosporins, it is excreted in breast milk in very small, clinically insignificant amounts; in 6 mothers taking it, the milk levels were undetectable. (Barr 1991)

Cephalosporins are widely used in paediatrics with very good tolerance, even from the neonatal period, so it is very unlikely that, in small quantities through milk, they can cause problems to the infant.

The possibility of gastroenteritis due to alteration of the intestinal flora must be taken into account. (Ito 1993)

Several medical societies and expert authors consider it safe to use this medication during breastfeeding. (Hale, LactMed, Briggs 2015)

Alternatives

We do not have alternatives for Ceftibuten since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Ceftibuten in other languages or writings:

Group

Ceftibuten belongs to this group or family:

Tradenames

Main tradenames from several countries containing Ceftibuten in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 75 - 90 %
Molecular weight 410 daltons
Protein Binding 65 - 77 %
VD 0.21 l/Kg
pKa 4.68 -
Tmax 2.6 hours
T½ 2.4 hours
Theoretical Dose 0 - < 0.15 mg/Kg/d
Relative Dose 0 - < 4 %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  4. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  5. Barr WH, Lin CC, Radwanski E, Lim J, Symchowicz S, Affrime M. The pharmacokinetics of ceftibuten in humans. Diagn Microbiol Infect Dis. 1991 Abstract

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