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Sacubitril is a prodrug that is metabolized to sacubitrilate (LBQ-657), a neprilysin inhibitor. It is administered orally twice daily in association with the angiotensin II receptor antagonist valsartan in the treatment of chronic heart failure.
It is excreted in breast milk in clinically non-significant amounts. (Falconi 2024)
Two infants whose mothers were taking sacubitril/valsartan did not present any problem. (Hale)