Last update July 6, 2018

Quinapril Hydrochloride

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Quinapril, via its active metabolite, quinaprilat, is an angiotensin converting enzyme inhibitor (ACEI) used in the treatment of high blood pressure and heart failure.
Oral administration every 12-24 hours.

It is excreted in breastmilk in clinically insignificant amounts (Anderson 2018, Begg 2001).
No problems have been observed in infants whose mothers were taking other ACEIs (Anderson 2018).

Due to its possible renal toxicity in preterm infants, it is preferable to avoid its use during the neonatal period in case of prematurity. (Serrano 2015).

The protective role of breastfeeding against maternal hypertension has been proven (Park 2018).

Alternatives

  • Captopril ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Enalapril ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
DONATE NOW

Other names

Quinapril Hydrochloride in other languages or writings:

Group

Quinapril Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Quinapril Hydrochloride in its composition:

List of 12 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 60 %
Molecular weight 475 daltons
Protein Binding 97 %
pKa 3.7 -
Tmax 2 hours
T½ 3 hours
M/P ratio 0.12 -
Relative Dose 1.6 %

References

  1. Park S, Choi NK. Breastfeeding and Maternal Hypertension. Am J Hypertens. 2018 Abstract
  2. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018 Abstract
  3. AEMPS. Quinapril. Ficha técnica. 2017 Full text (in our servers)
  4. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015 Jan 20;144(2):73-9. Abstract
  5. FDA. Quinapril. Drug Summary. 2013 Full text (in our servers)
  6. Begg EJ, Robson RA, Gardiner SJ, Hudson LJ, Reece PA, Olson SC, Posvar EL, Sedman AJ. Quinapril and its metabolite quinaprilat in human milk. Br J Clin Pharmacol. 2001 Abstract

Total visits

5,655

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2006 of United States of America

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM