Last update June 4, 2024

Sacubitril

Compatible

Safe substance and/or breastfeeding is the best option.

Sacubitril is a prodrug that is metabolized to sacubitrilate (LBQ-657), a neprilysin inhibitor. It is administered orally twice daily in association with the angiotensin II receptor antagonist valsartan in the treatment of chronic heart failure. 

It is excreted in breast milk in clinically non-significant amounts. (Falconi 2024)

Two infants whose mothers were taking sacubitril/valsartan did not present any problem. (Hale)

 

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Sacubitril in other languages or writings:

Group

Sacubitril belongs to this group or family:

Tradenames

Main tradenames from several countries containing Sacubitril in its composition:

List of 14 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 60 %
Molecular weight 412 daltons
VD 1.47 l/Kg
pKa 4.18 -
Tmax 0.5 - 2 hours
T½ 11.5 hours
Theoretical Dose 0.0014 mg/Kg/d
Relative Dose 0.22 %

References

  1. Falconi S, Okimi A, Wesley S, Sethi P, Datta P and Krutsch K. The concentration of maternal sacubitril/valsartan transferred into human milk is negligible. Front. Public Health. 12:1389513. doi: 10.3389/fpubh.2024.1389513 Consulted on June 4, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)

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