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Propantheline is a quaternary ammonium with antimuscarinic effects similar to those of atropine. It is used to treat urinary incontinence, hyperhidrosis, and bowel and bladder spasms. Oral administration 3 times a day.
At the date of the last update we did not find any published data on its excretion in breast milk.
Intestinal absorption is very low, reaching extremely low plasmatic levels or below the detection limit (Vose 1979), so it is highly unlikely that significant amounts will pass into breast milk.
This very low oral bioavailability, even lower if taken with food, minimizes the passage into plasma of the infant from ingested breast milk, except in the premature and in the immediate neonatal period in which there may be greater intestinal permeability.
Although antimuscarinics can decrease prolactin production (Müller 1983, Masala 1982), once lactation is established, milk production depends more on the repeated stimulation of suckling than on prolactin levels.