Last update Dec. 10, 2022

Propantheline Bromide

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Propantheline is a quaternary ammonium with antimuscarinic effects similar to those of atropine. It is used to treat urinary incontinence, hyperhidrosis, and bowel and bladder spasms. Oral administration 3 times a day.

At the date of the last update we did not find any published data on its excretion in breast milk.

Intestinal absorption is very low, reaching extremely low plasmatic levels or below the detection limit (Vose 1979), so it is highly unlikely that significant amounts will pass into breast milk.

This very low oral bioavailability, even lower if taken with food, minimizes the passage into plasma of the infant from ingested breast milk, except in the premature and in the immediate neonatal period in which there may be greater intestinal permeability.

Although antimuscarinics can decrease prolactin production (Müller 1983, Masala 1982), once lactation is established, milk production depends more on the repeated stimulation of suckling than on prolactin levels.


  • Otilonium Bromide (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Oxybutynin (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Propantheline Bromide in other languages or writings:


Propantheline Bromide belongs to this group or family:


Main tradenames from several countries containing Propantheline Bromide in its composition:


Variable Value Unit
Oral Bioavail. muy baja / very poor %
Molecular weight 448 daltons
pKa 17.63 -
3.2 (1.2 - 4.2) hours


  1. Müller EE, Locatelli V, Cella S, Peñalva A, Novelli A, Cocchi D. Prolactin-lowering and -releasing drugs. Mechanisms of action and therapeutic applications. Drugs. 1983 Apr;25(4):399-432. Review. Abstract
  2. Masala A, Alagna S, Devilla L, Rovasio PP, Rassa S, Faedda R, Satta A. Muscarinic receptor blockade by pirenzepine: effect on prolactin secretion in man. J Endocrinol Invest. 1982 Jan-Feb;5(1):53-5. Abstract
  3. Vose CW, Ford GC, Grigson SJ, Haskins NJ, Prout M, Stevens PM, Rose DA, Palmer RF, Rudel H. Pharmacokinetics of propantheline bromide in normal man. Br J Clin Pharmacol. 1979 Jan;7(1):89-93. No abstract available. Abstract Full text (link to original source)

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