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Pentazocine is an opioid analgesic derived from benzomorphan. It is used for the relief of moderate to severe pain, including labor pain. Oral, intramuscular, intravenous and subcutaneous administration.
A fecha de última actualización no encontramos datos publicados sobre su excreción en leche materna.
Its pharmacokinetic data (low molecular weight and moderate protein binding) makes transfer to breast milk possible, but its very high volume of distribution makes it difficult.
Its very low oral bioavailability (Sanofi 2018) minimizes the passage into plasma of the infant from ingested breast milk, except in the premature and in the immediate neonatal period in which there may be greater intestinal permeability.
It may increase prolactin levels. (Manner 1987)
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Sachs 2013), especially during the neonatal period and in the event of prematurity.