Last update Dec. 12, 2022
Likely Compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Pargeverine Hydrochloride is also known as
Pargeverine Hydrochloride in other languages or writings:
Pargeverine Hydrochloride belongs to this group or family:
Main tradenames from several countries containing Pargeverine Hydrochloride in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 75 ± 13 | % |
Molecular weight | 374 | daltons |
Protein Binding | 91 - 97 | % |
VD | 0.12 - 2 | l/Kg |
Tmax | 0.9 - 1 | hours |
T½ | 4 | hours |
M/P ratio | 0.1 | - |
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e-lactancia is a resource recommended by La Liga de la Leche de México of Mexico
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
A product which has antimuscarinic/anticholinergic effects, similar in action to atropine. It has antispasmodic properties on smooth muscle. Indicated in functional conditions of the intestine, gall bladder, uterus and bladder.
Since the last update, we have not found published data on its excretion in breastmilk.
Its high binding to plasma proteins makes its excretion in milk unlikely, as indicated by the manufacturer (Unipharm 2018).
There is hardly any published scientific data on this product: fewer than 10 articles (only 4 on humans) collected in PubMed and the last one dates from 2001.
Until there is more published information about this drug in relation to breastfeeding, better known alternatives may be preferable, especially during the neonatal period and in case of prematurity.
Although antimuscarinics can decrease prolactin production (Müller 1983, Masala 1982, De Martino 1980, Bizarro 1980), once lactation is established, milk production depends more on the repeated stimulation of suckling than on prolactin levels.
The literature on this drug is scarce and it is sold in few countries.
During breastfeeding it may be prudent to avoid it or take a minimum dose over short periods of time, monitoring the production of milk, especially in the first weeks postpartum. It is also advisable to monitor anticholinergic symptoms in the infant: dry mouth, constipation...