Last update Aug. 10, 2022
It is an opioid used in the management of moderate to severe pain. Its active metabolite, oxymorphone, is 14 times more potent than oxycodone (Dalal 2014). Very often used for treatment of pain associated to episiotomy or Cesarean section operation. Oral, subcutaneous or intravenous administration.
It is excreted in breast milk in a small amount, but it could be significant. (Seaton 2007, Marx 1986)
In a study with possible methodological biases (Rivers 2012), mild symptoms of central nervous system depression were observed in 20% of newborns breastfed by mothers taking oxycodone for postpartum analgesia (Lam 2012, Seaton 2007). Symptoms have occasionally been severe, with neurologic and respiratory depression, especially in the neonatal period (Beauchamp 2019, Timm 2013, Sulton 2012). No long-term problems have been seen in infants whose mothers were taking it. (Rampono 2007)
Dose should not be higher than 30 mg a day. (Lamvu 2018, Sachs 2013)
Women with some variants of enzyme-linked gene CYP2D6 who are on Oxycodone and their breastfed infants may experience increased sedation. (van den Anker 2012)
Overall, the use of opioids for pain control during labor and another 3 days is compatible with breastfeeding. The duration of opioid treatment should be limited to 3 days in unsupervised outpatient settings. (Ito 2018). Adequately use of nonsteroidal anti-inflammatory drugs (NSAIDs) may attain pain relief with less side effects than with narcotic analgesics.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America
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