Last update Jan. 17, 2021


Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is a meglitinide antidiabetic. It has a different structure from the sulfonylureas, but a similar mechanism of action. It induces endogenous insulin secretion and can cause hypoglycemia.
Nateglinide is indicated for combination therapy with metformin in type 2 diabetic patients.
Oral administration, before meals, three times a day.

We did not find published data regarding the excretion of this substance through breast milk at the time this last update was completed.

Its pharmacokinetic characteristics (very high plasma protein binding and a short half life) make it very unlikely its excretion into breast milk in significant amounts.

Diet, exercise, and breastfeeding improve blood sugar levels.

See below the information of this related product:


  • Glibenclamide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Hypocaloric Diet ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Insulin ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Metformin Hydrochloride ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

ナテグリニド is Nateglinide in Japanese.

Is written in other languages:


ナテグリニド belongs to this group or family:


Main tradenames from several countries containing ナテグリニド in its composition:


Variable Value Unit
Oral Bioavail. 73 %
Molecular weight 317 daltons
Protein Binding 98 %
VD 0.14 l/Kg
pKa 4 -
Tmax 1 hours
1.5 hours


  1. Novartis. Nateglinide. Drug Summary. 2008 Full text (in our servers)

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