Last update Jan. 17, 2021
Likely Compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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(-)-N-[(trans-4-Isopropylcyclohexyl)carbonyl]-d-phenylalanine is Nateglinide in Chemical name.
Is written in other languages:(-)-N-[(trans-4-Isopropylcyclohexyl)carbonyl]-d-phenylalanine belongs to this group or family:
Main tradenames from several countries containing (-)-N-[(trans-4-Isopropylcyclohexyl)carbonyl]-d-phenylalanine in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 73 | % |
Molecular weight | 317 | daltons |
Protein Binding | 98 | % |
VD | 0.14 | l/Kg |
pKa | 4 | - |
Tmax | 1 | hours |
T½ | 1.5 | hours |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
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It is a meglitinide antidiabetic. It has a different structure from the sulfonylureas, but a similar mechanism of action. It induces endogenous insulin secretion and can cause hypoglycemia.
Nateglinide is indicated for combination therapy with metformin in type 2 diabetic patients.
Oral administration, before meals, three times a day.
We did not find published data regarding the excretion of this substance through breast milk at the time this last update was completed.
Its pharmacokinetic characteristics (very high plasma protein binding and a short half life) make it very unlikely its excretion into breast milk in significant amounts.
Diet, exercise, and breastfeeding improve blood sugar levels.
See below the information of this related product: