フシジン酸

Fusidic acid and its salts such as sodium fusidate are antibacterials mainly used in the treatment of staphylococcal infections. Oral, intravenous and topical dermatological and ophthalmological administration.

Its pharmacokinetic data (moderately high molecular weight and high percentage of protein binding) explain the minimal passage into milk observed. ^{(Leo 2012 & 2010, Lauen 1969 cited in LactMed)}

Intestinal absorption is hindered by simultaneous feed intake, which minimises passage into the infant's plasma.

Authorised systemic use in neonates and infants It competes with bilirubin in binding to albumin, so in the first month of life and more so in premature infants, it is necessary to monitor the appearance of neonatal jaundice.

TOPICAL DERMATOLOGICAL USE:

Low absorption (0.54%) through the skin makes it unlikely that a significant amount will pass into breast milk. ^{(Leo 2017 & 2012)}

Not effective and may even be detrimental in the local treatment of cracks or nipple infections (Livingstone 1999) and mastitis. ^{(Crepinsek 2010)}