Last update Sept. 3, 2016

Fusidic Acid


Safe substance and/or breastfeeding is the best option.

At latest update no published data on excretion into breast milk were found.
Pharmacokinetic data (moderately high molecular weight and high percentage of protein binding capacity) make unlikely the milk passage of significant amounts.
Intestinal absorption is also impaired by simultaneous food intake, minimizing any passage toward infant’s plasma.

Systemic use is authorized in neonates and infants
Competes with the ability of bilirubin in binding to albumin, so during the first month of life and especially in premature, the occurrence of neonatal jaundice must be monitored.

Take into account possible negative results of bacterial cultures in febrile infants when their mothers are using antibiotics.

Poor absorption (0.54%) through the skin makes unlikely the passage of significant amount to breast milk.
Whenever necessary for treatment of infections in the nipple, apply right after breastfeed and let it to disaapear before the next feeding and if necessary remove excess with a gauze.
It should be avoided applying creams, gels and other products for local use on the nipple which could contain paraffin (mineral oil) in order to avoid any swallowing by the infant.


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Fusidic Acid is also known as

Fusidic Acid in other languages or writings:


Main tradenames from several countries containing Fusidic Acid in its composition:


Variable Value Unit
Oral Bioavail. 70 - 90. Derm: 0.5 %
Molecular weight 526 daltons
Protein Binding 95 %
Tmax 4 hours
10 - 15 hours


  1. Leo Pharma. Ácido fusídico, crema. Ficha técnica. 2012 Full text (in our servers)
  2. Leo Pharma. Ácido fusídico. Ficha técnica. 2010 Full text (in our servers)
  3. Crepinsek MA, Crowe L, Michener K, Smart NA. Interventions for preventing mastitis after childbirth. Cochrane Database Syst Rev. 2010 Abstract
  4. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  5. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  6. Turnidge J. Fusidic acid pharmacology, pharmacokinetics and pharmacodynamics. Int J Antimicrob Agents. 1999 Abstract
  7. Livingstone V, Stringer LJ. The treatment of Staphyloccocus aureus infected sore nipples: a randomized comparative study. J Hum Lact. 1999 Abstract

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