Last update May 1, 2016

Rifampicine

Compatible

Safe product and/or breastfeeding is the best option.

It is excreted into breast milk in clinically non-significant amount, in fact a much lower amount than the dose used for the treatment or prophylaxis of infection in neonates and infants. Even more, no problems that would be attributable to rifampicin have been observed among infants whose mothers were taking this medication.

It can cause an orange discoloration of body fluids, including the mother’s milk.
Take into account possible negative results in bacterial cultures of febrile infants, when their mothers are on antibiotics.

American Academy of Pediatrics states that it is usually compatible with breastfeeding medication.
WHO List of Essential Medicines 2002: compatible with breastfeeding.

Alternatives

We do not have alternatives for Rifampicine since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
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Other names

Rifampicine is also known as


Rifampicine in other languages or writings:

Group

Rifampicine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Rifampicine in its composition:

List of 18 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 95 %
Molecular weight 823 daltons
Protein Binding 84 - 91 %
VD 1.6 l/Kg
Tmax 2 - 3 hours
T½ 2 - 5 hours
M/P ratio 0.2 -
Theoretical Dose 0.15 - 0.74 mg/Kg/d
Relative Dose 1.5 - 7.4 %
Ped.Relat.Dose 0.75 - 7.5 %

References

  1. Algharably EA, Kreutz R, Gundert-Remy U. Infant Exposure to Antituberculosis Drugs via Breast Milk and Assessment of Potential Adverse Effects in Breastfed Infants: Critical Review of Data. Pharmaceutics. 2023 Apr 13;15(4). pii: 1228. Abstract Full text (link to original source)
  2. Partosch F, Mielke H, Stahlmann R, Gundert-Remy U. Exposure of Nursed Infants to Maternal Treatment with Ethambutol and Rifampicin. Basic Clin Pharmacol Toxicol. 2018 Aug;123(2):213-220. Abstract
  3. Ozturk Z, Tatliparmak A. Leprosy treatment during pregnancy and breastfeeding: A case report and brief review of literature. Dermatol Ther. 2017 Jan;30(1). Abstract
  4. Baquero-Artigao F, Mellado Peña MJ, del Rosal Rabes T, Noguera Julián A, Goncé Mellgren A, de la Calle Fernández-Miranda M, Navarro Gómez ML; Working Group on gestational, congenital, and postnatal tuberculosis, Spanish Society of Pediatric Infectious Diseases (PFIC). Guía de la Sociedad Española de Infectología Pediátrica sobre tuberculosis en la embarazada y el recién nacido (ii): profilaxis y tratamiento. [Spanish Society for Pediatric Infectious Diseases guidelines on tuberculosis in pregnant women and neonates (ii): Prophylaxis and treatment]. An Pediatr (Barc). 2015 Abstract Full text (link to original source) Full text (in our servers)
  5. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  6. Athavale MA, Maitra A, Patel S, Bhate VR, Toddywalla VS. Development of an in vitro cell culture model to study milk to plasma ratios of therapeutic drugs. Indian J Pharmacol. 2013 Abstract Full text (link to original source) Full text (in our servers)
  7. Sanofi. Rifampin. Product Monograph. 2010 Full text (in our servers)
  8. Mitrano JA, Spooner LM, Belliveau P. Excretion of antimicrobials used to treat methicillin-resistant Staphylococcus aureus infections during lactation: safety in breastfeeding infants. Pharmacotherapy. 2009 Sep;29(9):1103-9. Abstract
  9. AEMPS. Rifampicina. Ficha técnica. 2007 Full text (in our servers)
  10. Nahum GG, Uhl K, Kennedy DL. Antibiotic use in pregnancy and lactation: what is and is not known about teratogenic and toxic risks. Obstet Gynecol. 2006 Abstract
  11. Drobac PC, del Castillo H, Sweetland A, Anca G, Joseph JK, Furin J, Shin S. Treatment of multidrug-resistant tuberculosis during pregnancy: long-term follow-up of 6 children with intrauterine exposure to second-line agents. Clin Infect Dis. 2005 Jun 1;40(11):1689-92. Epub 2005 Apr 18. Abstract Full text (link to original source) Full text (in our servers)
  12. ATC. Blumberg HM, Burman WJ, Chaisson RE, Daley CL, Etkind SC, Friedman LN, Fujiwara P, Grzemska M, Hopewell PC, Iseman MD, Jasmer RM, Koppaka V, Menzies RI, O'Brien RJ, Reves RR, Reichman LB, Simone PM, Starke JR, Vernon AA; American Thoracic Society, Centers for Disease Control and Prevention and the Infectious Diseases Society. American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis. Am J Respir Crit Care Med. 2003 Abstract Full text (link to original source) Full text (in our servers)
  13. CDC. (American Thoracic Society); CDC; Infectious Diseases Society of America. Treatment of tuberculosis. MMWR Recomm Rep. 2003 Abstract Full text (link to original source) Full text (in our servers)
  14. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  15. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  16. Tran JH, Montakantikul P. The safety of antituberculosis medications during breastfeeding. J Hum Lact. 1998 Dec;14(4):337-40. Review. Abstract
  17. [No authors listed] American Thoracic Society. Medical Section of the American Lung Association: Treatment of tuberculosis and tuberculosis infection in adults and children. Am Rev Respir Dis. 1986 Abstract
  18. Snider DE Jr, Powell KE. Should women taking antituberculosis drugs breast-feed? Arch Intern Med. 1984 Abstract
  19. Vorherr H. Drug excretion in breast milk. Postgrad Med. 1974 Oct;56(4):97-104. Review. No abstract available. Abstract
  20. Lenzi E, Santuari S. Preliminary observations on the use of a new semi-synthetic rifamycin derivative in gynecology and obstetrics. Atti Accad Lancisiana Roma;13(Suppl 1):87–94. 1969

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