Last update Sept. 23, 2023
Decreased level of risk
New scientific evidences have driven the Apilam staff to update the level of risk associated to this product.
Former level of risk, which was Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment., is now set to Safe. Compatible. Minimal risk for breastfeeding and infant.
Level of risk reviewed on Sept. 23, 2023
Very Low Risk
A chelating agent that helps remove heavy metals such as copper, lead and mercury from the body. Used to treat Wilson's disease, cystinuria, severe rheumatoid arthritis and chronic active hepatitis.
It is excreted in breast milk in no or no detectable amount (Kodama 2021, Izumi 2012), and no clinical or analytical problems (Cu, Zn) have been observed in infants whose mothers took it. (Kodama 2021, Reuner 2019, Sternlieb 2000, Messner 1998, Bunke 1989, Gregory 1983)
Oral bioavailability decreases by half in the presence of food, so its passing to the infant’s plasma via ingested breast milk would be very difficult.
Copper and zinc levels in breast milk of mothers treated with penicillamine, trientine or zinc are normal according to more recent studies (Kodama 2021) and lower than normal according to older ones. (Bunke 1989)
Cases of breast hyperplasia and hyperprolactinemia have been reported in patients treated with penicillamine. (Craig 1988, Kahl 1985, Thew 1980)
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Thank you for helping to protect and promote breastfeeding.
e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2006 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM