Citalopram

SSRI antidepressant with actions and uses similar to those of fluoxetine. Oral administration once daily.

It is excreted in breast milk in small amounts although occasionally with a relative dose greater than 10%. ^{(Pogliani 2019, Schoretsanitis 2019, Weisskopf 2017, Rampono 2000, Schmidt 2000, Jensen 1997, Spigset 1997)}

Serum levels of infants from breastfeeding mothers who were treated have been shown to be undetectable or very low. ^{(Berle 2004, Heikkinen 2002, Nordeng 2001, Rampono 2000)}

Although there are some isolated cases of transient sleep disturbances, irritability or colic (Kronenfeld 2018, Schmidt 2000, Lee 2004), no short-term or long-term problems have been observed in the majority of infants whose mothers took it. ^{(Werremeyer 2009, Berle 2004, Hendrick 2003, Rampono 2000, Jensen 1997)}

Transient troubles in the early neonatal period like drug withdrawal syndrome among newborn or premature infants with high serum levels as a result of treatment with citalopram to the mother during pregnancy have been observed. ^{(Erol 2017, Kieviet 2015, Franssen 2006, Nordeng 2001)}

Galactorrhea associated or not to hyperprolactinemia, may appear. ^{(Türkoğlu 2016, Trenque 2011, Koch 2011, Wessels 2006, González 2001).}

Several medical societies, experts and expert consensus, consider the use of this medication safe or probably safe during breastfeeding. ^{(Hale, Lactmed, Uguz 2021, Rubin 2004, Wisner 2002)}

Safer known alternatives are preferable, especially during the neonatal period and in cases of prematurity. ^{(Weisskopf 2017, Sriraman 2015, Larsen 2015, Sachs 2013, Rowe 2013, Berle 2011, Patil 2011, Davanzo 2010, Lanza 2009, ABM 2008, Weissman 2004, Gjerdingen 2003, Nordeng 2001)}

Women suffering from depression during pregnancy need more breastfeeding support due to their increased risk of breastfeeding problems and early weaning. ^{(Grzeskowiak 2018, Leggett 2017, Gorman 2012)}

See below the information of this related product:

• Maternal Depression (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)